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The effective management on the\n                      <jats:italic>Phelipanche<\/jats:italic>\n                      and\n                      <jats:italic>Orobanche<\/jats:italic>\n                      parasitic weeds still remains challenging to date.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Novel strigolactone (SL) analogues (\n                      <jats:bold>X<\/jats:bold>\n                      series) and mimics (\n                      <jats:bold>O<\/jats:bold>\n                      series) derived from indolin\u20102\u2010one were designed and synthesized. Of them, compound\n                      <jats:bold>O\u20103<\/jats:bold>\n                      showed nearly ten\u2010fold higher seed germination activity (median effective concentration (EC\n                      <jats:sub>50<\/jats:sub>\n                      ) =\u20090.0066\u2009\u03bc\n                      <jats:sc>m<\/jats:sc>\n                      ) towards\n                      <jats:italic>Phelipanche aegyptiaca<\/jats:italic>\n                      seeds compared to the control GR24. Moreover, it also showed prominent seed germination activity towards\n                      <jats:italic>Phelipanche ramosa<\/jats:italic>\n                      . At a dosage of 0.2\u2009\u03bc\n                      <jats:sc>m<\/jats:sc>\n                      , the glasshouse experiment revealed that compound\n                      <jats:bold>O\u20103<\/jats:bold>\n                      not only displayed the profitable\n                      <jats:italic>P. aegyptiaca<\/jats:italic>\n                      control, but also influenced fruit and plant stalk development in tomato cultivation. Theoretical computational studies indicated that compound\n                      <jats:bold>O\u20103<\/jats:bold>\n                      could perfectly interact with catalytic triad of OmKAI2d4, and the oxime linker facilitate to release the active D ring species, thereby significantly improving bioactivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      A class of SL mimics incorporating a unique oxime linker has been developed from indolin\u20102\u2010one. Compound\n                      <jats:bold>O\u20103<\/jats:bold>\n                      exhibited the highest seed germination activities toward the parasitic\n                      <jats:italic>P. aegyptiaca<\/jats:italic>\n                      and\n                      <jats:italic>P. ramosa<\/jats:italic>\n                      , and could serve as a promising lead compound for the\n                      <jats:italic>Phelipanche<\/jats:italic>\n                      control. \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.8904","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T04:25:37Z","timestamp":1747283137000},"page":"5510-5523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design and synthesis of strigolactone analogues and mimics containing\n                    <scp>indolin<\/scp>\n        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