{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:56:56Z","timestamp":1792076216968,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017698","name":"Henan Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["2025ZC60"],"award-info":[{"award-number":["2025ZC60"]}],"id":[{"id":"10.13039\/501100017698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017698","name":"Henan Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["Z20241471130"],"award-info":[{"award-number":["Z20241471130"]}],"id":[{"id":"10.13039\/501100017698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Plant diseases caused by phytopathogenic fungi continue to threaten global food security, driving the urgent need for discovery of antifungal agrochemicals with novel modes of action. The motif of 1,5\u2010diaryl\u20103\u2010trifluoropyrazole was found to be associated with potential antifungal effect and\n                      <jats:bold>HNNK\u20105<\/jats:bold>\n                      was such an agrochemical being developed in our lab with moderate potency. This study took\n                      <jats:bold>HNNK\u20105<\/jats:bold>\n                      as the parent compound for lead optimization to discovery novel fungicides.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULT<\/jats:title>\n                    <jats:p>\n                      To further explore the antifungal potential of this class of compounds, a series of analogues of\n                      <jats:bold>HNNK\u20105<\/jats:bold>\n                      was designed and prepared. Among them, compound\n                      <jats:bold>7<\/jats:bold>\n                      was identified as the most potent member with much improved activity over the lead compound. Compound\n                      <jats:bold>7<\/jats:bold>\n                      almost completely inhibited the growth of all the tested fungal pathogens at 50\u2009\u03bcg\/mL with an EC\n                      <jats:sub>50<\/jats:sub>\n                      range of 6.2\u201311.5\u2009\u03bcg\/mL, multiple\u2010fold less potent than the positive control azoxystrobin. Scanning electronic microscope (SEM) observation and fatty acid analysis showed that compound\n                      <jats:bold>7<\/jats:bold>\n                      treatment caused morphological changes and altered the amount of fatty acids of\n                      <jats:italic>Fusarium oxysporum<\/jats:italic>\n                      . Furthermore, compound\n                      <jats:bold>7<\/jats:bold>\n                      at higher application rates showed pronounced controlling effects against peanut root rot disease caused by\n                      <jats:italic>Fusarium oxysporum<\/jats:italic>\n                      in field study,\n                      <jats:italic>similar<\/jats:italic>\n                      to those of positive control azoxystrobin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      This study indicated that the characteristic structure of 1,5\u2010diaryl\u20103\u2010trifluoropyrazole could be employed as a potential skeleton for antifungal pesticides development and provided compound\n                      <jats:bold>7<\/jats:bold>\n                      as a promising pesticide candidate for further development. \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.8909","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T05:46:13Z","timestamp":1748411173000},"page":"5571-5580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Discovery of novel 1,5\u2010diaryl\u20103\u2010trifluoropyrazoles as antifungal pesticides for crop protection"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-2402","authenticated-orcid":false,"given":"Yihui","family":"Ma","sequence":"first","affiliation":[{"name":"Plant Protection Institute Henan Academy of Agricultural Sciences  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dangwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Plant Protection Institute Henan Academy of Agricultural Sciences  Zhengzhou 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