{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:19:03Z","timestamp":1791814743684,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Natural green pesticides have become a global research hotspot, and identifying chemical structural frameworks with excellent biological activity has become the research direction of numerous researchers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Twenty chalcone derivatives incorporating 1,2,3,4\u2010tetrahydroquinoline scaffolds were systematically evaluated for their antibacterial activity against six plant pathogenic bacteria. Among the tested compounds, H1\u2013H10 exhibited superior\n                      <jats:italic>in vitro<\/jats:italic>\n                      inhibition against\n                      <jats:italic>Xanthomonas citri<\/jats:italic>\n                      pv.\n                      <jats:italic>mangiferaeindicae<\/jats:italic>\n                      (\n                      <jats:italic>Xcm<\/jats:italic>\n                      ) compared to Y1\u2013Y10. Notably, compound H6 demonstrated exceptional potency, with a median effective concentration (EC\n                      <jats:sub>50<\/jats:sub>\n                      ) value of 3.25\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      against\n                      <jats:italic>Xcm<\/jats:italic>\n                      , significantly surpassing the commercial agent (TC, EC\n                      <jats:sub>50<\/jats:sub>\n                      \u2009=\u200975.34\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ).\n                      <jats:italic>In vivo<\/jats:italic>\n                      efficacy trials revealed that H6 achieved 65.24% curative activity at 100\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      , outperforming TC (42.81%). Scanning electron microscopy further confirmed H6's disruptive effects on bacterial membrane integrity. Mechanistic studies targeting succinate dehydrogenase (SDH), a key respiratory enzyme, revealed structural and energetic similarities between H6 and the commercial SDH inhibitor bixafen through molecular docking and dynamics simulations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The 1,2,3,4\u2010tetrahydroquinoline moiety enhanced SDH binding affinity, while the introduced piperazine substructure in H6 improved both complex stability (root mean square deviation &lt;1.5\u2009\u00c5) and target engagement. These findings establish H6 as a promising lead compound for developing next\u2010generation SDH inhibitors, providing critical insights into structure\u2013activity relationships for agricultural antimicrobial design. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.8934","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T03:15:24Z","timestamp":1748488524000},"page":"5813-5826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Structural optimization of\n                    <scp>SDH<\/scp>\n                    \u2010targeting chalcone derivatives: piperazine\u2010driven binding stability against\n                    <scp>\n                      <i>Xanthomonas<\/i>\n                    <\/scp>\n                    pathogens"],"prefix":"10.1002","volume":"81","author":[{"given":"Tianyu","family":"Deng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&amp;D of Fine Chemicals of Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaini","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&amp;D of Fine Chemicals of Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&amp;D of Fine Chemicals of Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Center for R&amp;D of Fine Chemicals of Guizhou University  Guiyang 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