{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:23:07Z","timestamp":1789107787451,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005236","name":"Chinese Universities Scientific Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2025,9]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Succinate dehydrogenase inhibitor (SDHI) fungicides have been widely utilized in the combat of plant pathogenic fungi due to their potent, broad\u2010spectrum antifungal activity and unique mode of action. In this study, a series of novel 4\u2010sulfur\u2010substituted pyrazol\u20105\u2010yl\u2010benzamide derivatives containing amide, hydrazide, or ester moieties were synthesized to develop innovative SDH inhibitors.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n The bioassay studies indicated that several compounds exhibited potent\n in vitro<\/jats:italic>\n fungicidal activity against various fungi. Particularly, compound\n 4d<\/jats:bold>\n demonstrated broad\u2010spectrum fungicidal efficacy, with EC\n 50<\/jats:sub>\n values of 0.21, 0.95, 0.64, 1.33, and 0.66\u2009mg\u2009L\n \u22121<\/jats:sup>\n against\n Valsa mali<\/jats:italic>\n ,\n Botrytis cinerea<\/jats:italic>\n ,\n Rhizoctonia solani<\/jats:italic>\n ,\n Fusarium graminearum<\/jats:italic>\n , and\n Gaeumannomyces graminis<\/jats:italic>\n , respectively.\n In vivo<\/jats:italic>\n studies demonstrated that compound\n 4d<\/jats:bold>\n effectively prevented\n V. mali<\/jats:italic>\n infection in apples at 50\u2009mg\u2009L\n \u22121<\/jats:sup>\n , showing superior protective and curative effects (93.4% and 85.5%) compared to lead compound\n A27<\/jats:bold>\n (68.7% and 57.0%) and commercial fungicide\n fluxapyroxad<\/jats:bold>\n (55.4% and 43.6%). Enzymatic inhibition assays and molecular docking analysis suggested that compound\n 4d<\/jats:bold>\n could serve as a potential SDH inhibitor.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n This study offers valuable insights for expanding the fungicidal spectrum of pyrazol\u20105\u2010yl\u2010benzamide derivatives and further developing them as novel SDH inhibitors. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ps.8943","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:20:38Z","timestamp":1748910038000},"page":"5890-5902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Discovery of novel 4\u2010sulfur\u2010substituted pyrazol\u20105\u2010yl\u2010benzamide derivatives containing amide\/hydrazide\/ester moieties as potential succinate dehydrogenase inhibitors"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-7852","authenticated-orcid":false,"given":"Yantao","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection Northwest A&F University Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Mu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection Northwest A&F University Yangling 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