{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:18:36Z","timestamp":1760440716185},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,3,4]],"date-time":"2008-03-04T00:00:00Z","timestamp":1204588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The chemical synthesis by solid\u2010phase methods of a novel amphiphilic peptide, peptide\u2010conjugate amphiphile (PCA), containing in the same molecule three different functions: (i) the <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010bis[2\u2010[bis(carboxy\u2010ethyl)amino]ethyl]\u2010L\u2010glutamic acid (DTPAGlu) chelating agent, (ii) the CCK8 bioactive peptide, and (iii) a hydrophobic moiety containing four alkyl chains with 18 carbon atoms each, is reported. In water solution at pH 7.4, PCA self\u2010assembles in very stable micelles at very low concentration [critical micellar concentration (cmc) values of 5 \u00d7 10<jats:sup>\u22127<\/jats:sup> mol kg<jats:sup>\u22121<\/jats:sup>] as confirmed by fluorescence spectroscopy. The structural characterization, obtained with small\u2010angle neutron scattering (SANS) measurements, indicates that the aggregates are substantially represented by ellipsoidal micelles with an aggregation number of 39 \u00b1 2 and the two micellar axes of about 52 and 26 \u00c5. Copyright \u00a9 2008 European Peptide Society and John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/psc.1024","type":"journal-article","created":{"date-parts":[[2008,3,4]],"date-time":"2008-03-04T14:49:37Z","timestamp":1204642177000},"page":"903-910","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Micelles by self\u2010assembling peptide\u2010conjugate amphiphile: synthesis and structural characterization"],"prefix":"10.1002","volume":"14","author":[{"given":"Antonella","family":"Accardo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Tesauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Del 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