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Under these conditions it was possible to detect medium\u2010range NOEs for the first time for this peptide. This allowed a much better\u2010defined structure to be determined for Peptide T in comparison with earlier NMR and computational studies. Peptide structures consistent with the experimental restraints were generated using a restrained MD simulation with a full empirical force field. Residues 4\u20138 of Peptide T take on a well\u2010defined structure with a heavy atom RMSD of 0.78 \u00c5. The structure is stabilized by hydrogen bonding to side\u2010chain oxygen atoms of Thr 4 and Thr 8, as well as backbone hydrogen bonding between residues 5 and 7 that forms this region into a classic \u03b3\u2010turn. Copyright \u00a9 2009 European Peptide Society and John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/psc.1179","type":"journal-article","created":{"date-parts":[[2009,10,28]],"date-time":"2009-10-28T09:46:30Z","timestamp":1256723190000},"page":"818-823","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peptide T exhibits a well\u2010defined structure in fluorinated solvent at low temperature"],"prefix":"10.1002","volume":"15","author":[{"given":"Tran\u2010Chin","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Rendell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Gulliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Booth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,28]]},"reference":[{"issue":"4","key":"e_1_2_6_2_2","first-page":"482","article-title":"Peptide t[4\u20108]: A pentapeptide sequence in the aids virus envelope which blocks infectivity is essentially conserved across nine isolates","volume":"9","author":"Pert CB","year":"1986","journal-title":"Clin. neuropharmacol."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(03)00176-1"},{"key":"e_1_2_6_4_2","first-page":"117","article-title":"Peptide t and psoriasis","volume":"146","author":"Marcusson JA","year":"1989","journal-title":"Acta Derm. 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