{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:28:12Z","timestamp":1771936092355,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>We present the antimicrobial and hemolytic activities of the decapeptide anoplin and 19 analogs thereof tested against methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> ATCC 33591 (MRSA), <jats:italic>Escherichia coli<\/jats:italic> (ATCC 25922), <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (ATCC 27853), vancomycin\u2010resistant <jats:italic>Enterococcus faecium<\/jats:italic> (ATCC 700221) (VRE), and <jats:italic>Candida albicans<\/jats:italic> (ATCC 200955). The anoplin analogs contain substitutions in amino acid positions 2, 3, 5, 6, 8, 9, and 10. We use these peptides to study the effect of altering the charge and hydrophobicity of anoplin on activity against red blood cells and microorganisms. We find that increasing the charge and\/or hydrophobicity improves antimicrobial activity and increases hemolytic activity. For each strain tested, we identify at least six anoplin analogs with an improved therapeutic index compared with anoplin, the only exception being <jats:italic>Enterococcus faecium<\/jats:italic>, against which only few compounds are more specific than anoplin. Both 2Nal<jats:sup>6<\/jats:sup> and Cha<jats:sup>6<\/jats:sup> show improved therapeutic index against all strains tested. Copyright \u00a9 2013 European Peptide Society and John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/psc.2548","type":"journal-article","created":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T02:52:58Z","timestamp":1378781578000},"page":"669-675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Synthetic analogs of anoplin show improved antimicrobial activities"],"prefix":"10.1002","volume":"19","author":[{"given":"Jens K.","family":"Munk","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  DK 2100 Copenhagen \u00d8 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Erik","family":"Uggerh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chemistry and Environmental Engineering University of Aalborg  DK 9000 Aalborg 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