{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:03:52Z","timestamp":1790870632644,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21261130090"],"award-info":[{"award-number":["21261130090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21472109"],"award-info":[{"award-number":["21472109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2013CB910700"],"award-info":[{"award-number":["2013CB910700"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2012CB821600"],"award-info":[{"award-number":["2012CB821600"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>\n                    The abnormal accumulation of amyloid\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    (A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ) peptide in the brain is one of the most important hallmarks of Alzheimer's disease. A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    is an aggregation\u2010prone and toxic polypeptide with 39\u201343 residues, derived from the amyloid precursor protein proteolysis process. According to the amyloid hypothesis, abnormal accumulation of A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    in the brain is the primary influence driving Alzheimer's disease pathologies. Among all kinds of A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    isoforms, A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    40 and A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    42 are believed to be the most important ones. Although these two kinds of A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    differ only in two amino acid residues, recent studies show that they differ significantly in their metabolism, physiological functions, toxicities, and aggregation mechanism. In this review, we mainly summarize the similarities and differences between A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    42 and A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    40, recent studies on selective inhibitors as well as probes will also be mentioned. Copyright \u00a9 2015 European Peptide Society and John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/psc.2789","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T10:09:06Z","timestamp":1432807746000},"page":"522-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":175,"title":["A\n                    <i>\u03b2<\/i>\n                    42 and A\n                    <i>\u03b2<\/i>\n                    40: similarities and differences"],"prefix":"10.1002","volume":"21","author":[{"given":"Tian","family":"Qiu","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Fen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry Tsinghua University  Beijing 100084 China"},{"name":"Beijing Institute for Brain Disorders  Beijing 100069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69113-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0909142"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.3.022502.103022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3233\/JAD-2012-120253","article-title":"Increased protein\u2010conjugated acrolein and amyloid\u2010\u03b240\/42 ratio in plasma of patients with mild cognitive impairment and Alzheimer's disease","volume":"32","author":"Waragai M","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.02.015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2111583"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/325733a0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.741"},{"key":"e_1_2_9_12_1","first-page":"121","article-title":"Structural and kinetic features of amyloid \u03b2\u2010protein fibrillogenesis","volume":"5","author":"Teplow DB","year":"1998","journal-title":"Int. J. Exp. Clin. Invest."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00069a001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100528"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja8092604"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.264473"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja054041c"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn400208r"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04533"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90458-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2010.01137.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353442"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.06.005"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201200239"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.581165"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04404.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb34401.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/359325a0"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2168"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10737"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1456"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006304"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00463"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121560109"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb03306.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1635"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.17.11914"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1549-07.2007"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3376"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0997-1016"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp200530q"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2014.03.014"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218531"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009505"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-006-9221-9"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.94"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/198430"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23510"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2009.00456.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743132813Y.0000000195"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.08.088"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.211"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1nr11029b"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082139"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-864"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4849-06.2007"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.06.030"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20336"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/19\/38\/384010"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.2000.4288"},{"key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3233\/JAD-120850","article-title":"Prevention of amyloid\u2010\u03b2 fibril formation using antibodies against the C\u2010terminal region of amyloid\u2010\u03b21\u201040 and amyloid\u2010\u03b21\u201042","volume":"34","author":"Monta\u00f1\u00e9s M","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp808914c"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034345"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp2126366"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi200147a"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2013.11.016"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222681699"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.247"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja1117123"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4730410"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi902075h"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408153101"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-012-0909-9"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA05390G"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.37.22908"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401938"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.04.007"},{"key":"e_1_2_9_78_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3233\/JAD-2010-101341","article-title":"High\u2010affinity rabbit monoclonal antibodies specific for amyloid peptides amyloid\u2010\u03b240 and amyloid\u2010\u03b242","volume":"23","author":"Miller DL","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:20:1:15"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200400270"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja202908z"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn400011f"}],"container-title":["Journal of Peptide Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpsc.2789","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/psc.2789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:58:16Z","timestamp":1694584696000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/psc.2789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,28]]},"references-count":81,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/psc.2789"],"URL":"https:\/\/doi.org\/10.1002\/psc.2789","archive":["Portico"],"relation":{},"ISSN":["1075-2617","1099-1387"],"issn-type":[{"value":"1075-2617","type":"print"},{"value":"1099-1387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,28]]},"assertion":[{"value":"2014-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}