{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:40:22Z","timestamp":1790494822575,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u201cZhuoXue\u201d Talent Plan of Fudan University"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573340"],"award-info":[{"award-number":["81573340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Pept. Sci."],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1002\/psc.3014","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T07:27:29Z","timestamp":1496734049000},"page":"701-706","source":"Crossref","is-referenced-by-count":10,"title":["Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors"],"prefix":"10.1002","volume":"23","author":[{"given":"Hao","family":"Xu","sequence":"first","affiliation":[{"name":"Marine Science and Technology College; Zhejiang Ocean University; Zhoushan 316022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keting","family":"Bao","sequence":"additional","affiliation":[{"name":"School of Pharmacy; Fudan University; Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica; Chinese Academy of Sciences; Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ai","sequence":"additional","affiliation":[{"name":"Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica; Chinese Academy of Sciences; Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Marine Science and Technology College; Zhejiang Ocean University; Zhoushan 316022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4684-2911","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy; Fudan University; Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"10.1002\/psc.3014-BIB0001|psc3014-cit-0002","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1016\/S0021-9258(19)85585-0","article-title":"Biosynthesis of lysosomal enzymes in fibroblasts","volume":"255","author":"Hasilik","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1002\/psc.3014-BIB0002|psc3014-cit-0003","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/bst0180367","article-title":"Lysosomal enzyme targeting","volume":"18","author":"Kornfeld","year":"1990","journal-title":"Biochem. Soc. Trans."},{"key":"10.1002\/psc.3014-BIB0003|psc3014-cit-0004","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0300-9084(98)80013-8","article-title":"Isoforms of cathepsin D and human epidermal differentiation","volume":"80","author":"Horikoshi","year":"1998","journal-title":"Biochimie"},{"key":"10.1002\/psc.3014-BIB0004|psc3014-cit-0005","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.critrevonc.2008.02.008","article-title":"Cathepsin D-many functions of one aspartic protease","volume":"68","author":"Benes","year":"2008","journal-title":"Crit. Rev. Oncol. Hemat."},{"key":"10.1002\/psc.3014-BIB0005|psc3014-cit-0006","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.4161\/cbt.6.7.4325","article-title":"Depletion of procathepsin D gene expression by RNA interference-a potential therapeutic target for breast cancer","volume":"6","author":"Ohri","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"10.1002\/psc.3014-BIB0006|psc3014-cit-0007","first-page":"491","article-title":"The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells","volume":"32","author":"Ohri","year":"2008","journal-title":"Int. J. Oncol."},{"key":"10.1002\/psc.3014-BIB0007|psc3014-cit-0008","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.biochi.2010.05.009","article-title":"Pathophysiological functions of cathepsin D: targeting its catalytic activity versus its protein binding activity?","volume":"92","author":"Masson","year":"2010","journal-title":"Biochimie"},{"key":"10.1002\/psc.3014-BIB0008|psc3014-cit-0009","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0959-8049(95)00530-7","article-title":"Cathepsin D and breast cancer","volume":"32","author":"Westley","year":"1996","journal-title":"Eur. J. Cancer"},{"key":"10.1002\/psc.3014-BIB0009|psc3014-cit-0010","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/stem.140642","article-title":"Biological and clinical significance of cathepsin D in breast cancer metastasis","volume":"14","author":"Garcia","year":"1996","journal-title":"Stem Cells"},{"key":"10.1002\/psc.3014-BIB0010|psc3014-cit-0011","first-page":"87","article-title":"Cathepsin D, a novel target for apoptotic induction, as a future anti-cancer therapy","volume":"2","author":"Chaudhary","year":"2012","journal-title":"J. Phys. Pharm. Adv."},{"key":"10.1002\/psc.3014-BIB0011|psc3014-cit-0012","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/0959-8049(92)90003-K","article-title":"Cathepsin D in breast cancer: a tissue marker associated with metastasis","volume":"28","author":"Rochefort","year":"1992","journal-title":"Eur. J. Cancer"},{"key":"10.1002\/psc.3014-BIB0012|psc3014-cit-0013","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/sj.bjc.6690032","article-title":"Prognostic value of cathepsin D in breast cancer","volume":"79","author":"Westley","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1002\/psc.3014-BIB0013|psc3014-cit-0014","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.canlet.2005.06.007","article-title":"Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis","volume":"237","author":"Liaudet-Coopman","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1002\/psc.3014-BIB0014|psc3014-cit-0015","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/S0960-894X(99)00433-3","article-title":"Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors","volume":"9","author":"Dumas","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1002\/psc.3014-BIB0015|psc3014-cit-0016","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1016\/j.bmcl.2006.06.010","article-title":"Synthesis of gallic acid based naphthophenone fatty acid amides as cathepsin D inhibitors","volume":"16","author":"Srivastava","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1002\/psc.3014-BIB0016|psc3014-cit-0017","first-page":"687","article-title":"Identification of sulfmoylbenzamide derivatives as selective cathepsin D inhibitors","volume":"26","author":"Ahmed","year":"2013","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1002\/psc.3014-BIB0017|psc3014-cit-0018","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/pro.5560060710","article-title":"Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors","volume":"6","author":"Majer","year":"1997","journal-title":"Protein Sci."},{"key":"10.1002\/psc.3014-BIB0018|psc3014-cit-0019","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1016\/S0960-894X(98)00554-X","article-title":"Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D","volume":"8","author":"Carroll","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1002\/psc.3014-BIB0019|psc3014-cit-0020","doi-asserted-by":"crossref","first-page":"9735","DOI":"10.1021\/ja981812m","article-title":"General solid-phase synthesis approach to prepare mechanism-based aspartyl protease inhibitor libraries. Identification of potent cathepsin D inhibitors","volume":"120","author":"Lee","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"10.1002\/psc.3014-BIB0020|psc3014-cit-0021","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jconrel.2013.07.017","article-title":"Dipeptide mimic oligomer transporter mediates intracellular delivery of cathepsin D inhibitors: a potential target for cancer therapy","volume":"171","author":"Maynadier","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1002\/psc.3014-BIB0021|psc3014-cit-0022","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/cmdc.201500457","article-title":"Structure-activity relationships of JMV4463, a vectorized cathepsin D inhibitor with antiproliferative properties: the unique role of the AMPA-based vector","volume":"11","author":"Vezenkov","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1002\/psc.3014-BIB0022|psc3014-cit-0023","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/psc.1051","article-title":"Total synthesis and stereochemical reassignment of tasiamide","volume":"14","author":"Ma","year":"2008","journal-title":"J. Pept. Sci."},{"key":"10.1002\/psc.3014-BIB0023|psc3014-cit-0024","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1016\/j.bmc.2012.05.077","article-title":"Total synthesis of grassystatin A, a probe for cathepsin E function","volume":"20","author":"Yang","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1002\/psc.3014-BIB0024|psc3014-cit-0025","doi-asserted-by":"crossref","first-page":"10\u00a0749","DOI":"10.1021\/jm301630s","article-title":"Cyanobacterial peptides as a prototype for the design of potent \u03b2-secretase inhibitors and the development of selective chemical probes for other aspartic proteases","volume":"55","author":"Liu","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1002\/psc.3014-BIB0025|psc3014-cit-0026","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.bmc.2015.03.034","article-title":"Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors","volume":"23","author":"Liu","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1002\/psc.3014-BIB0026|psc3014-cit-0027","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3390\/md14050085","article-title":"Novel azetidine-containing TZT-1027 analogues as antitumor agents","volume":"14","author":"Yan","year":"2016","journal-title":"Mar. Drugs."},{"key":"10.1002\/psc.3014-BIB0027|psc3014-cit-0028","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1021\/acs.orglett.6b02780","article-title":"Total synthesis and biological evaluation of apratoxin E and its C30 epimer: configurational reassignment of the natural product","volume":"18","author":"Wu","year":"2016","journal-title":"Org. Lett."},{"key":"10.1002\/psc.3014-BIB0028|psc3014-cit-0029","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/psc.1254","article-title":"Total synthesis and stereochemical reassignment of tasiamide B","volume":"16","author":"Sun","year":"2010","journal-title":"J. Pept. Sci."},{"key":"10.1002\/psc.3014-BIB0029|psc3014-cit-0030","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1021\/jm061338s","article-title":"Design, synthesis, and X-ray structure of potent memapsin 2 (\u03b2-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands","volume":"50","author":"Ghosh","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1002\/psc.3014-BIB0030|psc3014-cit-0031","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1021\/jm0304008","article-title":"Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human \u03b2-secretase","volume":"47","author":"Hom","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1002\/psc.3014-BIB0031|psc3014-cit-0032","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1021\/jm049379g","article-title":"Structure-based design of a series of potent and selective cell-permeable inhibitors of human \u03b2-secretase (BACE-1)","volume":"47","author":"Stachel","year":"2004","journal-title":"J. Med. Chem."}],"container-title":["Journal of Peptide Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpsc.3014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/psc.3014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T15:48:54Z","timestamp":1719244134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/psc.3014"}},"subtitle":["Design and Synthesis of Cath D Inhibitors"],"short-title":[],"issued":{"date-parts":[[2017,6,6]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"URL":"https:\/\/doi.org\/10.1002\/psc.3014","archive":["Portico"],"relation":{},"ISSN":["1075-2617"],"issn-type":[{"value":"1075-2617","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6,6]]}}}