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We showed that ACE could hydrolyse gastrin, a neuropeptide from the gastrointestinal tract, releasing the C\u2010terminal amidated dipeptide H\u2010Asp\u2010Phe\u2010NH<jats:sub>2<\/jats:sub>. This dipeptide is believed to be involved in the gastrin\u2010induced acid secretion in the stomach. This hypothetic mechanism of action of gastrin resulted in a strategy to rationally design gastrin receptor antagonists. Beyond, we showed that the brain renin angiotensin system (RAS) could be activated by a new characterized peptide named acein, resulting in stimulation of dopamine release within the striatum. This new and original \u2018receptor\u2010like\u2019 activity for brain membrane\u2010bound ACE is quite significant taking into account the role of dopamine in the brain, particularly in neurodegenerative diseases. 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