{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:00:36Z","timestamp":1785891636252,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006316","name":"Drug Research Academy, K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p><jats:italic>Staphylococcus pseudintermedius<\/jats:italic> is the predominant opportunistic pathogen in dogs causing primarily integumentary infections such as pyoderma and otitis. The worldwide emergence of methicillin\u2010resistant <jats:italic>S. pseudintermedius<\/jats:italic> (MRSP) constitutes a significant health problem for companion animals in veterinary medicine. Thus, discovery of novel agents for treatment of MRSP\u2010associated infections is highly warranted. In the present work, structure\u2010activity relationships (based on testing of 37 peptidomimetics) have been explored with the aim of determining the influence of oligomer length as well as effect of fluorination, end\u2010group modification, and length of hydrophobic side chains. Incorporation of fluorine atoms and elongation of hydrophobic side chains both conferred overall increased potency without significantly enhancing the hemolytic properties of the compounds. Importantly, it was found that when targeting MRSP, the peptidomimetic length could be reduced from 12 to 8 residues without substantial loss of antibacterial activity. By contrast, introduction of end\u2010group modifications did not improve the activity against MRSP (10 strains tested), but conferred increased activity against <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content>, <jats:italic>Escherichia coli<\/jats:italic>, and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, albeit the concomitantly increased hemolytic properties resulted in a slightly lowered cell selectivity.<\/jats:p>","DOI":"10.1002\/psc.3098","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T07:24:46Z","timestamp":1530516286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fluorinated antimicrobial lysine\u2010based peptidomimetics with activity against methicillin\u2010resistant <i>Staphylococcus pseudintermedius<\/i>"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-4508","authenticated-orcid":false,"given":"Natalia","family":"Molchanova","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Universitetsparken 2 DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9357-8001","authenticated-orcid":false,"given":"Paul R.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Universitetsparken 2 DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-5996","authenticated-orcid":false,"given":"Peter","family":"Damborg","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Stigb\u00f8jlen 4 1870 Frederiksberg C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2822-1927","authenticated-orcid":false,"given":"Henrik","family":"Franzyk","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Universitetsparken 2 DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Antimicrobial resistance: Global report on surveillance","author":"W. 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