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The obtained compounds were tested for the antibacterial and antifungal activity. All novel dendrimers displayed much better activity against the tested strains than FMDP itself. Moreover, their conjugates with FMDP also exhibited antimicrobial activity. The most promising molecules were tested against a broad selection of fungal strains. The analysis of their antifungal properties indicates that the examined molecules are efficient growth inhibitors of fluconazole\u2010resistant hospital\u2010acquired strains. Moreover, an application of amphiphilic branched peptides such as FMDP carriers suggests that transport mechanism involves more likely the cell membrane perturbation than the mediation of the specific transport proteins. The activity of obtained compounds strongly depends on the specific structure of the molecule.<\/jats:p>","DOI":"10.1002\/psc.3226","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T07:18:35Z","timestamp":1576567115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Peptide dendrimers as antifungal agents and carriers for potential antifungal agent\u2014<i>N<\/i><sup>3<\/sup>\u2010(4\u2010methoxyfumaroyl)\u2010(<i>S<\/i>)\u20102,3\u2010diaminopropanoic acid\u2014synthesis and antimicrobial activity"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7976-633X","authenticated-orcid":false,"given":"Magdalena","family":"Stolarska","sequence":"first","affiliation":[{"name":"National Medicines Institute  Warszaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6750-3217","authenticated-orcid":false,"given":"Katarzyna","family":"Gucwa","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Gda\u0144sk University of Technology  Gda\u0144sk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zofia","family":"Urba\u0144czyk\u2010Lipkowska","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Polish Academy of Science  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryszard","family":"Andruszkiewicz","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Gda\u0144sk University of Technology  Gda\u0144sk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/587101"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-147-7-1955"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01648-07"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.10.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2012.01667.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2007.03.032"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050145"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1986.tb01041.x"},{"issue":"4","key":"e_1_2_7_10_1","first-page":"295","article-title":"Antifungal activity of thionated analogues of Nva\u2010FMDP and Lys\u2010Nva\u2010FMDP","volume":"58","author":"Nowak\u2010Jary J","year":"2009","journal-title":"Pol J Microbiol."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.12.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.06.016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00315-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.582039"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00393a005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20849"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.8b00544"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22469"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc800125u"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2017.03.016"},{"issue":"4","key":"e_1_2_7_21_1","first-page":"1197","article-title":"Iyer AK","volume":"18","author":"Luong D","year":"2017","journal-title":"Polyvalent folate\u2010dendrimer\u2010coated iron oxide theranostic nanoparticles for simultaneous magnetic resonance imaging and precise cancer cell targeting Biomacromolecules"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2016-0064"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33553"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.1999.00498.x"},{"key":"e_1_2_7_25_1","unstructured":"CLSI. 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