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In previous study, Esc\u20101GN with anti\u2010inflammatory, antimicrobial, and lipopolysacchride (LPS) binding activity was identified from the skin of the frog <jats:styled-content style=\"fixed-case\"><jats:italic>Hylarana guentheri<\/jats:italic><\/jats:styled-content>. Here, we report its therapeutic potentials for acne vulgaris and inflammatory pain. Esc\u20101GN destroyed the cell membrane of <jats:italic>Propionibacteria acnes<\/jats:italic> in the membrane permeability assays. In addition, bacterial agglutination test suggested that Esc\u20101GN triggered the agglutination of <jats:italic>P. acnes<\/jats:italic>, which was affected by LPS and Ca<jats:sup>2+<\/jats:sup>. Meanwhile, in vivo anti\u2010<jats:italic>P. acnes<\/jats:italic> and anti\u2010inflammatory effects of Esc\u20101GN were confirmed by reducing the counts of <jats:italic>P. acnes<\/jats:italic> in mice ear, relieving <jats:italic>P. acnes<\/jats:italic>\u2010induced mice ear swelling, decreasing mRNA expression and the production of pro\u2010inflammatory cytokines, and attenuating the infiltration of inflammatory cells. Moreover, Esc\u20101GN also displayed antinociceptive effect in mice induced by acetic acid and formalin. Therefore, Esc\u20101GN is a promising candidate drug for treatment of acne vulgaris and inflammatory pain.<\/jats:p>","DOI":"10.1002\/psc.3269","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T02:50:58Z","timestamp":1592535058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Esc\u20101GN shows therapeutic potentials for acne vulgaris and inflammatory pain"],"prefix":"10.1002","volume":"26","author":[{"given":"Tiaofei","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Zhujiang Hospital Southern Medical University  Guangzhou 510282 China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences Southern Medical University  Guangzhou 510060 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