{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:17:40Z","timestamp":1791433060360,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"crossref","award":["2017YFD0501404"],"award-info":[{"award-number":["2017YFD0501404"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Presently, echinocandins have been recommended as the first\u2010line drugs for the treatment of invasive candidiasis. However, low oral bioavailability and solubility limit their application. To improve this situation, this study chose amino acid and fatty acid as raw materials to modify the nucleus of echinocandin B. Six N\u2010acylated analogs were screened from the derivatives that possessed potent antifungal activity and good water solubility. Based on antifungal susceptibility and hemolytic toxicity, compound <jats:bold>5<\/jats:bold> as the candidate had good antifungal activity and no hemolytic effect. Moreover, compared with anidulafungin, compound <jats:bold>5<\/jats:bold> showed a comparable fungicidal effect, much higher solubility, and lower toxicity. In conclusion, compound <jats:bold>5<\/jats:bold> has the potential for further research and development on account of reserved antifungal activity, high solubility, and low toxicity.<\/jats:p>","DOI":"10.1002\/psc.3278","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T07:56:07Z","timestamp":1596441367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The synthesis and activity evaluation of N\u2010acylated analogs of echinocandin B with improved solubility and lower toxicity"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8445-2201","authenticated-orcid":false,"given":"Bing","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Pharmacy Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhen","family":"Dong","sequence":"additional","affiliation":[{"name":"Shanghai Duomirui Biotechnology Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[{"name":"Shanghai Duomirui Biotechnology Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Duomirui Biotechnology Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sida","family":"Ruan","sequence":"additional","affiliation":[{"name":"State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry  Shanghai China"},{"name":"Shanghai Duomirui Biotechnology Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2015.1028366"},{"issue":"7","key":"e_1_2_6_4_1","first-page":"453","article-title":"Invasive candidiasis and candidemia: new guidelines","volume":"75","author":"De Rosa FG","year":"2009","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.08.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M237"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.3.369"},{"issue":"12","key":"e_1_2_6_9_1","first-page":"1327","article-title":"Anidulafungin (Eli Lilly & co)","volume":"2","author":"Hawser S","year":"1999","journal-title":"IDrugs"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr2104w"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(08)70023-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.5.1.45"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2016.89"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00399-07"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01569-10"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00160-09"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-82502010000300013"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.11.2326"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2015.07.008"},{"key":"e_1_2_6_20_1","first-page":"117","article-title":"Phase\u2010solubility techniques","volume":"4","author":"Higuchi TA","year":"1965","journal-title":"Adv Anal Chem Instrum"},{"key":"e_1_2_6_21_1","first-page":"1","article-title":"Andrographolide inhibits inflammatory cytokines secretion in LPS\u2010stimulated RAW264.7 cells through suppression of NF\u2010kappa B\/MAPK signaling pathway","volume":"2017","author":"Li Y","year":"2017","journal-title":"Evid\u2010Based Compl Alt"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12629-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1356-9597.2001.00495.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1916-3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00502-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.8.1811"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.1.57-62.2000"}],"container-title":["Journal of Peptide Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpsc.3278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/psc.3278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/psc.3278","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/psc.3278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T20:10:14Z","timestamp":1693944614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/psc.3278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,3]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/psc.3278"],"URL":"https:\/\/doi.org\/10.1002\/psc.3278","archive":["Portico"],"relation":{},"ISSN":["1075-2617","1099-1387"],"issn-type":[{"value":"1075-2617","type":"print"},{"value":"1099-1387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,3]]},"assertion":[{"value":"2020-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3278"}}