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Toxins are able to bind to calcium channels and block them. Ca<jats:sup>2+<\/jats:sup> ions play an important role in many cell processes, in particular, in apoptosis. In this work, we study the effect of some arthropod toxins on intracellular processes associated with the induction of apoptosis.<\/jats:p><jats:p>Synthetic analogs of U<jats:sub>5<\/jats:sub>\u2010scytotoxin\u2010Sth1a, \u03c9\u2010hexatoxin\u2010Hv1a, \u03c9\u2010theraphotoxin\u2010Hhn2a, and \u03bc\u2010agatoxin\u2010Aa1a toxins\u2014inhibitors of calcium L, P, and Q channels and sodium channels were used in the study. Apoptosis was induced by AC\u20101001 H3 peptide. We study the effect of toxins on the level of apoptosis, ROS, mitochondrial potential, GSH, and ATP in CHO\u2010K1 cells.<\/jats:p><jats:p>We show that all the tested toxins are able to dose dependently block the induction of apoptosis triggered by AC\u20101001 H3 and reduce the level of natural apoptosis in CHO\u2010K1 cells. Cell incubation with apoptosis inducer AC\u20101001 H3 in the presence and absence of toxins causes an increase in the intracellular concentrations of ROS, ATP, and mitochondrial potential and decreases the GSH concentration.<\/jats:p><jats:p>The present study reveals the antiapoptotic effect of a number of arthropod peptide toxins. The toxins studied can represent a novel approach used in the treatment of pathologies associated with the activation of apoptotic mechanisms.<\/jats:p>","DOI":"10.1002\/psc.3288","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T01:16:20Z","timestamp":1603070180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arthropod toxins inhibiting Ca<sup>2+<\/sup> and Na<sup>+<\/sup> channels prevent AC\u20101001 H3 peptide\u2010induced apoptosis"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7484-2671","authenticated-orcid":false,"given":"Elena","family":"Iurova","sequence":"first","affiliation":[{"name":"S. P. Kapitsa Technological Research Institute Ulyanovsk State University  Ulyanovsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenii","family":"Beloborodov","sequence":"additional","affiliation":[{"name":"S. P. 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