{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:44:15Z","timestamp":1787507055712,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["VXO #2017\/03046\u20102"],"award-info":[{"award-number":["VXO #2017\/03046\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>\n                    VmCT1, a linear helical antimicrobial peptide isolated from the venom of the scorpion\n                    <jats:italic>Vaejovis mexicanus<\/jats:italic>\n                    , displays broad spectrum antimicrobial activity against bacteria, fungi, and protozoa. Analogs derived from this peptide containing single Arg\u2010substitutions have been shown to increase antimicrobial and antiparasitic activities against\n                    <jats:italic>Trypanossoma cruzi<\/jats:italic>\n                    . Here, we tested these analogs against malaria, an infectious disease caused by\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    protozoa, and assessed their antitumoral properties. Specifically, we tested VmCT1 synthetic variants [Arg]\n                    <jats:sup>3<\/jats:sup>\n                    \u2010VmCT1\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    , [Arg]\n                    <jats:sup>7<\/jats:sup>\n                    \u2010VmCT1\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    , and [Arg]\n                    <jats:sup>11<\/jats:sup>\n                    \u2010VmCT1\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    , against\n                    <jats:italic>Plasmodium gallinaceum<\/jats:italic>\n                    sporozoites and MCF\u20107 mammary cancer cells. Our screen identified peptides [Arg]\n                    <jats:sup>3<\/jats:sup>\n                    \u2010VmCT1\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    and [Arg]\n                    <jats:sup>7<\/jats:sup>\n                    \u2010VmCT1\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    as potent antiplasmodial agents (IC\n                    <jats:sub>50<\/jats:sub>\n                    of 0.57 and 0.51 \u03bcmol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively), whereas [Arg]\n                    <jats:sup>11<\/jats:sup>\n                    \u2010VmCT1\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    did not show activity against\n                    <jats:italic>P. gallinaceum<\/jats:italic>\n                    sporozoites. Interestingly, all peptides presented activity against MCF\u20107 and displayed lower cytotoxicity toward healthy cells. We demonstrate that increasing the net positive charge of VmCT1, through arginine substitutions, modulates the biological properties of this peptide family yielding novel antiplasmodial and antitumoral molecules.\n                  <\/jats:p>","DOI":"10.1002\/psc.3296","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T13:23:08Z","timestamp":1610716988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Net charge tuning modulates the antiplasmodial and anticancer properties of peptides derived from scorpion venom"],"prefix":"10.1002","volume":"27","author":[{"given":"Cibele Nicolaski","family":"Pedron","sequence":"first","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas Universidade Federal do ABC  Santo Andr\u00e9 SP 09210580 Brazil"},{"name":"Departamento de Biof\u00edsica Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo SP 04044020 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Science University of Pennsylvania  Philadelphia PA 19102 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyntia Silva de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Biof\u00edsica Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo SP 04044020 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine Patricia","family":"Andrade","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas Universidade Federal do ABC  Santo Andr\u00e9 SP 09210580 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Cerchiaro","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas Universidade Federal do ABC  Santo Andr\u00e9 SP 09210580 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aparecida Silva","family":"Pinhal","sequence":"additional","affiliation":[{"name":"Departamento de Biof\u00edsica Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo SP 04044020 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"de la Fuente\u2010Nunez","sequence":"additional","affiliation":[{"name":"Machine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine University of Pennsylvania  Philadelphia PA 19102 USA"},{"name":"Departments of Bioengineering and Chemical and Biomolecular Engineering, School of Engineering and Applied Science University of Pennsylvania  Philadelphia PA 19102 USA"},{"name":"Penn Institute for Computational Science University of Pennsylvania  Philadelphia PA 19102 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9420-0956","authenticated-orcid":false,"given":"Vani Xavier","family":"Oliveira 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