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As an extremely oxidation\u2010sensitive and low\u2010abundance amino acid, methionine emerges as a promising target for chemo\u2010 and site\u2010selective modification. Herein we report an efficient and highly selective modification on methionine residues by one\u2010pot O\u2010 and N\u2010transfer reaction, generating sulfoximine\u2010modified peptides with near\u2010perfect conversion within 10\u00a0min. Moreover, the great tolerance to other natural amino acids has been demonstrated in reactions with various peptide substrates. To demonstrate the generality of this protocol, we have modified natural peptides and obtained sulfoximination products with high conversion rates. This methodology provides a novel strategy as the expansion of the methionine\u2010based peptide functionalization toolbox.<\/jats:p>","DOI":"10.1002\/psc.3454","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T10:28:50Z","timestamp":1664620130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A rapid and selective methionine oxidative modification strategy"],"prefix":"10.1002","volume":"29","author":[{"given":"Meng\u2010Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Yang","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry Tsinghua University  Beijing 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