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Derivatives of FP modulator (6<jats:italic>S<\/jats:italic>)\u2010<jats:bold>2<\/jats:bold> were synthesized, possessing respectively 5\u2010 and 7\u2010hydroxyl groups on the indolizidin\u20102\u2010one amino acid (I<jats:sup>2<\/jats:sup>aa) residue. The effects of the alcohol substituents were examined in a PGF2\u03b1\u2010induced myometrial contraction assay. Based on knowledge of dihedral angle values of model I<jats:sup>2<\/jats:sup>aa peptides from X\u2010ray analyses, the results of the study indicate respectively encouraging and limited potential for creating improved tocolytic agents by modifications at the 5\u2010 and 7\u2010positions.<\/jats:p>","DOI":"10.1002\/psc.3455","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T04:58:30Z","timestamp":1664773110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of 5\u2010 and 7\u2010hydroxy indolizidin\u20102\u2010one prostaglandin\u2010F<sub>2\u03b1<\/sub> modulators and activity on myometrial contractility towards development of agents for delaying preterm 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