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The infection mechanism of SARS\u2010CoV\u20102 consists of several stages, and each one can be selectively blocked to disrupt viral infection. Peptides are a promising class of antiviral compounds, which may be suitably modified to be more stable, more effective, and more selective towards a specific viral replication step. The latter two goals might be obtained by increasing the specificity and\/or the affinity of the interaction with a specific target and often imply the stabilization of the secondary structure of the active peptide. This review is focused on modified antiviral peptides against SARS\u2010CoV\u20102 acting at different stages of virus replication, including ACE2\u2010RBD interaction, membrane fusion mechanism, and the proteolytic cleavage by different viral proteases. Therefore, the landscape presented herein provides a useful springboard for the design of new and powerful antiviral therapeutics.<\/jats:p>","DOI":"10.1002\/psc.3541","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:29:42Z","timestamp":1694564982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chemically modified antiviral peptides against SARS\u2010CoV\u20102"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-3405","authenticated-orcid":false,"given":"Michael","family":"Quagliata","sequence":"first","affiliation":[{"name":"Interdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry \u201cUgo Schiff\u201d University of Florence  Sesto Fiorentino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna 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