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Interestingly, water plays a structuring role because at 1% v\/v, it enables dipeptide self\u2010assembly in MeCN to yield organogels, which then undergo transition towards crystals. Other organic solvents and oils were tested for gelation, and metastable gels were formed in tetrahydrofuran, although at high peptide concentration (80\u2009mM). Single\u2010crystal X\u2010ray diffraction revealed the dipeptides' supramolecular packing modes in amphipathic layers, as opposed to water channels reported for the homochiral Leu\u2013Leu, or hydrophobic columns reported for homochiral Leu\u2013Val and Leu\u2013Ile.<\/jats:p>","DOI":"10.1002\/psc.3559","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T08:08:12Z","timestamp":1702973292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Self\u2010assembly of heterochiral, aliphatic dipeptides with Leu"],"prefix":"10.1002","volume":"30","author":[{"given":"Erica","family":"Scarel","sequence":"first","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"De Corti","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Polentarutti","sequence":"additional","affiliation":[{"name":"Elettra Sincrotrone Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-6077","authenticated-orcid":false,"given":"Giovanni","family":"Pierri","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology \u201cA. 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