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The rapid spread and accumulation of mutations into viruses, and the limited availability of antiviral drugs and vaccines, stress the urgent need for alternative therapeutic strategies. Antimicrobial peptides (AMPs) derived from natural sources present a promising avenue due to their specificity and effectiveness against a broad spectrum of pathogens. The present study focuses on investigating the antiviral potential of oreochromicin\u20101 (oreoch\u20101), a fish\u2010derived AMP obtained from Nile tilapia, against a wide panel of animal viruses including canine distemper virus (CDV), Schmallenberg virus (SBV), caprine herpesvirus 1 (CpHV\u20101), and bovine herpesvirus 1 (BoHV\u20101). Oreoch\u20101 exhibited a strong antiviral effect, demonstrating an inhibition of infection at concentrations in the micromolar range. The mechanism of action involves the interference with viral entry into host cells and a direct interaction between oreoch\u20101 and the viral envelope. In addition, we observed that the peptide could also interact with the cell during the CDV infection. These findings not only highlight the efficacy of oreoch\u20101 in inhibiting viral infection but also emphasize the potential of fish\u2010derived peptides, specifically oreoch\u20101, as effective antiviral agents against viral infections affecting animals, whose potential to spill into humans is high. This research contributes valuable insights to the ongoing quest for novel antiviral drugs with the potential to mitigate the impact of infectious diseases on a global scale.<\/jats:p>","DOI":"10.1002\/psc.3593","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:49:50Z","timestamp":1710290990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Oreoch\u20101: A broad\u2010spectrum virus and host\u2010targeting peptide against animal infections"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8822-2841","authenticated-orcid":false,"given":"Bianca M.","family":"Nastri","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Campania \u201cLuigi Vanvitelli\u201d Naples 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