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Within this discussion, we delve into the diverse array of synthetic peptide\u2010based anticancer vaccines, each derived from tumor\u2010associated antigens (TAAs), including melanoma antigen recognized by T cells 1 (Melan\u2010A or MART\u20101), mucin 1 (MUC1), human epidermal growth factor receptor 2 (HER\u20102), tumor protein 53 (p53), human telomerase reverse transcriptase (hTERT), survivin, folate receptor (FR), cancer\u2010testis antigen 1 (NY\u2010ESO\u20101), and prostate\u2010specific antigen (PSA). We also describe the synthetic peptide\u2010based vaccines developed for cancers triggered by oncovirus, such as human papillomavirus (HPV), and hepatitis C virus (HCV). Additionally, the potential synergy of peptide\u2010based vaccines with common therapeutics in cancer was considered. The last part of our discussion deals with the realm of the peptide\u2010based vaccines delivery, highlighting its role in translating the most promising candidates into effective clinical strategies. 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