{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:15:33Z","timestamp":1790990133111,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Short neuropeptide F (sNPF) is a peptide unique to insects, characterized by a C\u2010terminal phenylalanine and a conserved RLRFa motif, and plays key roles in controlling feeding behavior, growth, circadian rhythms, and water\u2013salt homeostasis. We previously identified an sNPF analog, I\u20103, with aphidicidal activity. In this study, 10 sNPF analogs with aromatic or nonaromatic modifications at the N\u2010terminus were designed based on I\u20103, using molecular docking and peptidomimetic strategies to investigate the role of N\u2010terminal residues. Aphicidal activity showed that A\u20101 has stronger activity than I\u20103 and pymetrozine. Structure\u2013activity analysis indicated that a benzene ring with electronegative and lipophilic groups at the N\u2010terminus is key for aphicidal activity. Molecular docking and molecular dynamics simulations showed A\u20101 binds more stably to the receptor than I\u20103. Toxicity tests on honeybees (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Apis mellifera<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) confirm that compound A\u20101, which exhibits strong aphidicidal activity, is safe for nontarget organisms. Additionally, Admetsar3 evaluations indicate low toxicity risks for all compounds. Therefore, A\u20101 represents a promising, selective, and eco\u2010friendly insecticide for controlling pea aphids, and this study validates the feasibility of developing novel green pesticides based on sNPF.\n                  <\/jats:p>","DOI":"10.1002\/psc.70065","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:09:58Z","timestamp":1764054598000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rational Design, Synthesis, and Aphicidal Activity of Novel Insect Short Neuropeptide Analogs as Potential Aphid Control Agents"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3343-9357","authenticated-orcid":false,"given":"Yuanlin","family":"Zhou","sequence":"first","affiliation":[{"name":"College of Chemical Engineering, Department of Pharmaceutical Engineering Sichuan University of Science &amp; Engineering  Zigong Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyue","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Department of Pharmaceutical Engineering Sichuan University of Science &amp; Engineering  Zigong Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"An","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Department of Pharmaceutical Engineering Sichuan University of Science &amp; Engineering  Zigong Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Department of Pharmaceutical Engineering Sichuan University of Science &amp; Engineering  Zigong Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Department of Pharmaceutical Engineering Sichuan University of Science &amp; Engineering  Zigong Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoduo","family":"Guan","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Department of Pharmaceutical Engineering Sichuan University of Science &amp; 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