{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:02:37Z","timestamp":1780470157614,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human bone morphogenetic protein\u20102 (BMP2) is an effective osteoinductor in bone formation and growth via binding to its cognate receptors and coreceptors. Traditionally, the protein is identified to possess a conformational\n                    <jats:italic>wrist<\/jats:italic>\n                    epitope and a linear\n                    <jats:italic>knuckle<\/jats:italic>\n                    epitope that can be recognized by type I and type II receptors, respectively. In this study, we defined an additional epitope termed\n                    <jats:italic>elbow<\/jats:italic>\n                    as the specific binding site of its coreceptor, which is concentrated into a small helical hairpin region of BMP2 monomer 1 and partially overlaps with\n                    <jats:italic>wrist<\/jats:italic>\n                    but is far away from\n                    <jats:italic>knuckle<\/jats:italic>\n                    . A linear\n                    <jats:italic>l<\/jats:italic>\n                    EEP peptide is derived from the\n                    <jats:italic>elbow<\/jats:italic>\n                    epitope, which, however, is intrinsically disordered and cannot be maintained in native helical hairpin conformation due to lack of BMP2 protein context support, thus only exhibiting a low affinity to coreceptor. Disulfide stapling strategy is then used to stabilize the helical hairpin conformation of linear\n                    <jats:italic>l<\/jats:italic>\n                    EEP, which results in its two cyclic counterparts. The stapling is demonstrated to effectively improve peptide affinity and also exhibits a high selection for coreceptor over type\u2010I receptor. The cyclic peptides are found to maintain a well\u2010ordered, native\u2010like conformation, which can be readily recognized by coreceptor through a conformational selection mechanism.\n                  <\/jats:p>","DOI":"10.1002\/psc.70088","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:32:26Z","timestamp":1769844746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of Human Bone Morphogenetic Protein\u20102\n                    <i>Elbow<\/i>\n                    Epitope as Its Coreceptor Recognition Site and Design of\n                    <i>Elbow<\/i>\n                    \u2010Derived Hairpin Peptides to Specifically Target the Coreceptor"],"prefix":"10.1002","volume":"32","author":[{"given":"Yan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Danyang Hospital of Traditional Chinese Medicine Teaching Hospital of Nanjing University of Chinese Medicine  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianming","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Danyang Hospital of Traditional Chinese Medicine Teaching Hospital of Nanjing University of Chinese Medicine  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5471-9346","authenticated-orcid":false,"given":"Jinpeng","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Danyang Hospital of Traditional Chinese Medicine Teaching Hospital of Nanjing University of Chinese Medicine  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jdb8030019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022327"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.11.008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199603000-00006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2001.149"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb756"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.13.3314"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10930-020-09937-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CP00407A"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-022-00725-z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4550-11.2011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2024.24"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202200175"},{"key":"e_1_2_10_15_1","first-page":"1","article-title":"Genome\u2010Wide 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