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Peptide\u2010based therapeutics offer high molecular specificity and favorable safety profiles; however, their clinical utility remains largely limited by reliance on parenteral delivery. Oral administration is strategically attractive for improving patient adherence, quality of life, and healthcare efficiency, yet peptide drugs face formidable gastrointestinal barriers, including enzymatic degradation, restricted epithelial permeability, and substantial pharmacokinetic variability. These challenges may be further exacerbated by treatment\u2010related gastrointestinal dysfunction in oncology populations. This review critically evaluates oral peptide nano\u2010formulations that incorporate molecular permeation enhancers with established regulatory precedence as a pragmatic approach to achieving clinically meaningful oral absorption in breast cancer. 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