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The ACE2 interaction interface with the SARS\u2010CoV\u20102 spike protein was utilized to design an ACE2\u2010derived peptide sequence (FD11) that targeted the viral spike protein. It was found to be non\u2010cell penetrating, while in\u00a0vivo studies revealed the non\u2010cytotoxic nature of the peptide molecule. The minimum effective concentration of the peptide was found to be 10\u2009\u03bcM with 95% cell viability in Vero E6 cell line. The IC\n                    <jats:sub>50<\/jats:sub>\n                    of the peptide was found to be around 6.4\u2009\u03bcM. Treatment of the peptide in SARS\u2010CoV\u20102 infected Vero E6 cells was found to decrease the infectivity as compared to control. This presents a simple approach where host\u2010pathogen protein interaction\u2010interface derived peptides can be used for binding with substrate macromolecules to target and modulate pathogen infectivity.\n                  <\/jats:p>","DOI":"10.1002\/psc.70097","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T05:52:12Z","timestamp":1779947532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protection of SARS\u2010CoV\u20102 Infection by Targeting Viral Spike Protein With De Novo Designed ACE2\u2010Derived Undecapeptide"],"prefix":"10.1002","volume":"32","author":[{"given":"Anindya","family":"Dutta","sequence":"first","affiliation":[{"name":"BITS\u2010BioCyTIH Foundation Birla Institute of Technology and Science (BITS) Pilani  Mormugao South Goa India"},{"name":"Bose Institute  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilanjan","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Bose Institute  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soushruti","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Bose Institute  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Sen","sequence":"additional","affiliation":[{"name":"CSIR\u2010Indian Institute of Chemical Biology (IICB)  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"CSIR\u2010Indian Institute of Chemical Biology (IICB)  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Dutta","sequence":"additional","affiliation":[{"name":"Bose Institute  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuladip","family":"Jana","sequence":"additional","affiliation":[{"name":"Bose Institute  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopeswar","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Barasat Cancer Research and Welfare Centre  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samit","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"BITS\u2010BioCyTIH Foundation Birla Institute of Technology and Science (BITS) Pilani  Mormugao South Goa India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhrangsu","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Bose Institute  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73162-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71188-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(20)30004-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00490-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015303"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007236"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00418-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1288686"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.04.022"},{"key":"e_1_2_10_11_1","first-page":"1","volume-title":"Coronaviruses: Methods and Protocols","author":"Fehr A. 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