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In this study, a series of peptide\u2013heterocycle conjugates was systematically designed and synthesized using solid\u2010phase peptide synthesis (SPPS), featuring octapeptide\u2010triazole conjugates modified with a triazole\u2010based moiety. Non\u2010proteinogenic amino acids, specifically 2\u2010aminoisobutyric acid (Aib) and 2\u2010naphthylalanine (2\u2010Nal), were used to add structural diversity. SPPS is a relatively easy way to synthesize these compounds, which ensures accuracy in the sequence. The synthesized peptides were subjected to an antimicrobial activity assessment following a molecular docking study. In comparison to the standard drug, compound\n                    <jats:bold>7e<\/jats:bold>\n                    exhibited promising antibacterial activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    , with the MIC value of 12\u2009\u03bcg\/mL, whereas compound\n                    <jats:bold>7a<\/jats:bold>\n                    showed enhanced activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    with the MIC value of 12\u2009\u03bcg\/mL. Compound\n                    <jats:bold>7a<\/jats:bold>\n                    exhibited better to moderate antifungal activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    , with the MIC values of 25\u2009\u03bcg\/mL.\n                  <\/jats:p>","DOI":"10.1002\/psc.70122","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:55:17Z","timestamp":1788429317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Peptide\u2013Triazole Conjugates: Strategic Synthesis, Antimicrobial Properties, and Molecular Docking 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