{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:50:52Z","timestamp":1792065052186,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The global rise of multidrug\u2010resistant (MDR) pathogens has created an urgent need for alternative antimicrobial agents. In this study, we evaluated the antibacterial activity of LTX\u2010315, a synthetic cationic 9\u2010mer peptide originally developed as an oncolytic agent, against six ATCC reference strains and six clinical isolates, including methicillin\u2010resistant\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (MRSA), extended\u2010spectrum \u03b2\u2010lactamase (ESBL)\u2013producing\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    <\/jats:styled-content>\n                    , MDR\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Stenotrophomonas maltophilia<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Burkholderia cepacia<\/jats:italic>\n                    <\/jats:styled-content>\n                    . LTX\u2010315 exhibited broad\u2010spectrum antibacterial activity, with MICs of 8\u201332\u2009\u03bcM against reference strains and as low as 4\u2009\u03bcM against several MDR clinical isolates, whereas chloramphenicol and kanamycin were ineffective. Double\u2010disk diffusion assays indicated synergistic interactions with aminoglycosides, chloramphenicol, and vancomycin, and checkerboard assays confirmed synergy\u2010to\u2010additivity interactions with gentamicin and vancomycin against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (FICI 0.38\u20130.75), yielding fourfold to 16\u2010fold reductions in antibiotic dose. These findings demonstrate that LTX\u2010315 retains potent activity against clinically relevant MDR pathogens and may serve as both a standalone antimicrobial peptide and a potential antibiotic adjuvant.\n                  <\/jats:p>","DOI":"10.1002\/psc.70137","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:02:11Z","timestamp":1791421331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating LTX\u2010315 as a Therapeutic Peptide: Antimicrobial Activity on Clinical Bacterial Isolates"],"prefix":"10.1002","volume":"32","author":[{"given":"Hoan Tran","family":"Khanh","sequence":"first","affiliation":[{"name":"Faculty of Medical Technology Phenikaa University  Hanoi Vietnam"},{"name":"Microbiology Department Phenikaa University Hospital (PhenikaaMec)  Hanoi 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