{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:55:08Z","timestamp":1786978508606,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has been proved that the principal component of senile plaques is aggregates of \u03b2\u2010amyloid peptide (A\u03b2) in cases of one of the most common forms of age\u2010related neurodegenerative disorders, Alzheimer's disease (AD). Although the synthetic methods for the synthesis of A\u03b2 peptides have been developed since their first syntheses, A\u03b2[1\u201042] is still problematic to prepare. The highly hydrophobic composition of A\u03b2[1\u201042] results in aggregation between resin\u2010bound peptide chains or intrachain aggregation which leads to a decrease in the rates of deprotection and repetitive incomplete coupling reactions during 9\u2010flurenylmethoxycarbonyl (Fmoc) synthesis. In order to avoid aggregation and\/or disrupt internal aggregation during stepwise Fmoc solid phase synthesis and to improve the quality of crude products, several attempts have been made. Since highly pure A\u03b2 peptides in large quantities are used in biological experiments, we wanted to develop a method for a rational synthesis of human A\u03b2[1\u201042] with high purity and adequate yield.<\/jats:p>\n                  <jats:p>\n                    This paper reports a convenient methodology with a novel solvent system for the synthesis of A\u03b2[1\u201042], its\n                    <jats:italic>N<\/jats:italic>\n                    \u2010terminally truncated derivatives A\u03b2[4\u201042] and A\u03b2[5\u201042], and A\u03b2[1\u201042] labeled with 7\u2010amino\u20104\u2010methyl\u20103\u2010coumarinylacetic acid (AMCA) at the\n                    <jats:italic>N<\/jats:italic>\n                    \u2010terminus using Fmoc strategy. The use of 10% anisole in Dimethylformamide\/Dichloromethane (DMF\/DCM) can substantially improve the purity and yield of crude A\u03b2[1\u201042] and has been shown to be an optimal coupling condition for the synthesis of A\u03b2[1\u201042]. Anisole is a cheap and simple aid in the synthesis of \u2018difficult sequences\u2019 where other solvents are less successful in the prevention of aggregation during the synthesis. Copyright \u00a9 2006 European Peptide Society and John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/psc.801","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T05:08:15Z","timestamp":1163740095000},"page":"94-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Synthesis of A\u03b2[1\u201042] and its derivatives with improved efficiency"],"prefix":"10.1002","volume":"13","author":[{"given":"M\u00e1rta","family":"Zar\u00e1ndi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"So\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Bozs\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Datki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor K.","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botond","family":"Penke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90008-A"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-02-00376.1992"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90131-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(92)90061-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(92)90062-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929866043406986"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0021-9258(18)48529-8","article-title":"Assembly and aggregation properties of synthetic Alzheimer's A4\/b amyloid peptide analogs","volume":"267","author":"Burdick D","year":"1992","journal-title":"J. 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