{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:27:06Z","timestamp":1764602826383},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T00:00:00Z","timestamp":1188345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Peptide Science"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human amylin (1\u201337) and the (1\u201313) fragment were synthesized with and without pseudoproline dipeptides. Thallium (III) trifluoroacetate, a mild oxidant, was used to cyclize the peptides by forming a disulfide bridge from C<jats:sup>2<\/jats:sup> to C<jats:sup>7<\/jats:sup>. On the basis of our model studies, incorporation of a pseudoproline dipeptide decreases the amount of time necessary for the crude linear amylin (1\u201313) to cyclize on the resin. Without pseudoproline dipeptides, the 1\u201337 crude linear amylin was not pure enough to undergo the cyclization reaction. Following the cyclization studies, the synthesis time of the linear human amylin (1\u201337) was systematically reduced from 58 h to 8.5 h by shortening the reaction times. Cyclization and cleavage times were also reduced to 1.5 h. Copyright \u00a9 2007 European Peptide Society and John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/psc.909","type":"journal-article","created":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T09:46:35Z","timestamp":1188380795000},"page":"833-838","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Fast Fmoc synthesis of hAmylin<sub>1\u201337<\/sub> with pseudoproline assisted on\u2010resin disulfide formation"],"prefix":"10.1002","volume":"13","author":[{"given":"Karen","family":"Page","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina A.","family":"Hood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirendra","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahendra","family":"Menakuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae H.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.6.752"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.11.3881"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8628"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol047480"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja961509q"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/psc.484"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200200546"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(03)00141-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1387(199909)5:9<403::AID-PSC213>3.0.CO;2-S"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol016891c"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.35.2339"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3011.2001.00936.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00075a040"},{"key":"e_1_2_1_15_2","unstructured":"URL: http:\/\/www.emdbiosciences.com\/html\/NBC\/pseudopro line1.htm[Last accessed May 2007]."},{"key":"e_1_2_1_16_2","unstructured":"FuentesG HoodC PageK PatelH ParkJH MenakuruM. 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