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The best route to achieve the analogues possessing the three\u2010dimensional arrangement corresponding to the native binding loop was the introduction of constraint by ring formation via side chain to side chain lactamization for suitably protected Lys and Glu residues. Since tryptophane residue located at position 14 of this neuropeptide has been suggested as essential for binding, analogues in which this amino acid was replaced by aza\u2010tryptophane and alanine were synthesized. The synthesis was carried out on various acid\u2010labile resins (BARLOS chlorotrityl, Rink amide, PEG\u2010based or Wang resins), by Fmoc strategy. In this paper, we describe optimization of the peptide cyclization with various protecting groups, and on resin or in solution cyclization experimental parameters. 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