{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:20:34Z","timestamp":1769854834424,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CPT Pharmacom &amp; Syst Pharma"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Hormonal contraceptive agents (<jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>s) are widely used throughout the world, and women taking <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>s are likely to take other medications. However, little is known about the clinical effect of most drug\u2010drug interactions (<jats:styled-content style=\"fixed-case\">DDI<\/jats:styled-content>s) associated with <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>s. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate <jats:styled-content style=\"fixed-case\">DDI<\/jats:styled-content> impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a <jats:styled-content style=\"fixed-case\">DDI<\/jats:styled-content>\u2010prediction framework to inform optimal use of <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1002\/psp4.12357","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T10:05:18Z","timestamp":1538042718000},"page":"706-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Establishing a Multidisciplinary Framework to Study Drug\u2010Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate"],"prefix":"10.1002","volume":"7","author":[{"given":"Lawrence J.","family":"Lesko","sequence":"first","affiliation":[{"name":"Center for Pharmacometrics and Systems Pharmacology Department of Pharmaceutics College of Pharmacy University of Florida  Lake Nona (Orlando) Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valvanera","family":"Vozmediano","sequence":"additional","affiliation":[{"name":"Center for Pharmacometrics and Systems Pharmacology Department of Pharmaceutics College of Pharmacy University of Florida  Lake Nona (Orlando) Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almut","family":"Winterstein","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Bill &amp; Melinda Gates Foundation  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Lippert","sequence":"additional","affiliation":[{"name":"Clinical Pharmacometrics Bayer AG Pharmaceuticals  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"H\u00f6chel","sequence":"additional","affiliation":[{"name":"Bayer AG  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayyappa","family":"Chaturvedula","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annesha","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Center for Pharmacometrics and Systems Pharmacology Department of Pharmaceutics College of Pharmacy University of Florida  Lake Nona (Orlando) Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"United Nations Department of Economic and Social Affairs PD.Trends in contraceptive use Worldwide 2015. Contraception.1\u201370p.<https:\/\/doi.org\/10.1016\/j.contraception> (2015). Accessed 29 August 2012."},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2007.09.013"},{"key":"e_1_2_6_3_1","unstructured":"Centers for Disease Control and Prevention (CDC).How effective are birth control methods \u2013 reversible methods of birth control. <https:\/\/www.cdc.gov\/reproductivehealth\/contraception\/index.htm>."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2007.00702.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015910792246254"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2015.03.006"},{"key":"e_1_2_6_7_1","unstructured":"US Food and Drug Administration.Labeling for combined hormonal contraceptives guidance for industry. <https:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM590673.pdf> (2017). Accessed 10 January 2018."}],"container-title":["CPT: Pharmacometrics &amp; Systems Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpsp4.12357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/psp4.12357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:54:12Z","timestamp":1694739252000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/psp4.12357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,23]]},"references-count":7,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/psp4.12357"],"URL":"https:\/\/doi.org\/10.1002\/psp4.12357","archive":["Portico"],"relation":{},"ISSN":["2163-8306","2163-8306"],"issn-type":[{"value":"2163-8306","type":"print"},{"value":"2163-8306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,23]]},"assertion":[{"value":"2018-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}