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Primary injury sites of\n                    <jats:styled-content style=\"fixed-case\">drug\u2010induced kidney injury<\/jats:styled-content>\n                    are proximal tubules. Clinically, kidney injury molecule\u20101, an established tubule\u2010specific biomarker, is monitored to assess the presence and progression of injury. The ability to accurately predict drug\u2010related nephrotoxicity preclinically would reduce patient burden and drug attrition rates, yet state\u2010of\u2010the\u2010art\n                    <jats:italic>in vitro<\/jats:italic>\n                    and animal models fail to do so. In this study, we demonstrate the use of kidney injury molecule\u20101 measurement in the kidney\n                    <jats:styled-content style=\"fixed-case\">microphysiological system<\/jats:styled-content>\n                    as a preclinical model for drug toxicity assessment. To show clinical relevance, we use quantitative systems pharmacology computational models for\n                    <jats:italic>in vitro\u2013in vivo<\/jats:italic>\n                    translation of the experimental results and to identify favorable dosing regimens for one of the tested drugs.\n                  <\/jats:p>","DOI":"10.1002\/psp4.12400","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T05:25:23Z","timestamp":1552541123000},"page":"316-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Translational Assessment of Drug\u2010Induced Proximal Tubule Injury Using a Kidney Microphysiological System"],"prefix":"10.1002","volume":"8","author":[{"given":"Christian","family":"Maass","sequence":"first","affiliation":[{"name":"Department of Biological Engineering Massachusetts Institute of Technology  Cambridge Massachusetts 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