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The Migraine\u2010Specific Quality\u2010of\u2010Life Questionnaire (MSQ) is a 14\u2010item patient\u2010reported outcome instrument that measures the impact of migraine on health\u2010related quality of life. Erenumab data from four phase II\/III clinical trials were used to develop an item response theory (IRT) model within a nonlinear mixed effects framework, (i) evaluate the MSQ item information with respect to patient disability, (ii) characterize the longitudinal progression of the MSQ, and (iii) quantify the effect of erenumab on the MSQ in patients with migraine. The majority (80%) of information was found to be contained in 9 out of 14 items, extending the current knowledge on the reliability of the MSQ as a psychometric tool. Simulations across three MSQ domains show significant improvement from baseline, exceeding minimally important differences. 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