{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:25:48Z","timestamp":1792772748421,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CPT Pharmacom &amp; Syst Pharma"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Approximately 15% of patients suspected of having Parkinson's disease (PD) present dopamine active transporter (DaT) scans without evidence of dopaminergic deficits (SWEDD), most of which will never develop PD. Leveraging Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS) scores from the Parkinson's Progression Markers Initiative, three different models of varying complexity, (total score, item response theory (IRT)\u00a0and artificial neural network (ANN)) were evaluated to determine their ability to differentiate between PD and SWEDDs. Each of the models provided as output a predicted probability of having PD (P\n                    <jats:sub>DeNoPD<\/jats:sub>\n                    ). Both the IRT and ANN methods performed well as classifiers; ROC AUC &gt;\u200980%, sensitivity &gt;\u200993%, and precision ~90% when assuming a probability cutoff of P\n                    <jats:sub>DeNoPD<\/jats:sub>\n                    \u2009\u2265\u200950%. Specificity was 43% and 38% for IRT and ANN respectively. Matthews correlation coefficient (MCC) was also evaluated as a metric to address potential bias of majority positive class. At all cutoffs at or above 50%, the IRT and ANN model performed similarly and achieved a MCC of at least 0.3, indicating at least a moderate positive relationship for classifier performance. In contrast, the total score model was a poor classifier, for all metrics and cutoffs. Using item\u2010level data the proposed methodologies differentiated PD patients from SWEDDs with a degree of sensitivity and specificity that may compete with clinical examination and could aid in selecting DaTscan candidates. The choice of cutoff criteria, quality metric, and classifier model are contingent upon specific clinical needs.\n                  <\/jats:p>","DOI":"10.1002\/psp4.70000","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:57:08Z","timestamp":1741633028000},"page":"881-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Item Response Modeling and Artificial Neural Network for Differentiation of Parkinson's Patients and Subjects Without Evidence of Dopaminergic Deficit"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-1657","authenticated-orcid":false,"given":"Leticia","family":"Arrington","sequence":"first","affiliation":[{"name":"Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2799-7643","authenticated-orcid":false,"given":"Sven C.","family":"van Dijkman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-3904","authenticated-orcid":false,"given":"Elodie L.","family":"Plan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1258-8297","authenticated-orcid":false,"given":"Mats O.","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010017\u20101686\u2010y"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization \u201cParkinson Disease \u201dhttps:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/parkinson\u2010disease accessed July 1 2024."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010211\u201045295\u20100_3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of Clinical Diagnosis of Idiopathic Parkinson's Disease: A Clinico\u2010Pathological Study of 100 Cases","volume":"55","author":"Hughes A. J.","year":"1992","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"e_1_2_10_6_1","first-page":"237","article-title":"Accuracy of Clinical Diagnosis of Parkinson Disease: A Systematic Review and Meta\u2010Analysis","volume":"86","author":"Rizzo G. C. M.","year":"2016","journal-title":"Neurology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1212\/WNL.0000000000002876","article-title":"Comment & Author Response on: Accuracy of Clinical Diagnosis of Parkinson Disease: A Systematic Review and Meta\u2010Analysis","volume":"87","author":"Jellinger K. A.","year":"2016","journal-title":"Neurology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS Clinical Diagnostic Criteria for Parkinson's Disease","volume":"30","author":"Postuma R. B.","year":"2015","journal-title":"Movement Disorders"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/mds.21198","article-title":"Movement Disorder Society\u2010Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS): Process, Format, and Clinimetric Testing Plan","volume":"22","author":"Goetz C. G.","year":"2007","journal-title":"Movement Disorders"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)61393\u20103"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.2489\u201018"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/jnnp-2014-310256","article-title":"What Do Patients With Scans Without Evidence of Dopaminergic Deficit (SWEDD) Have? New Evidence and Continuing Controversies","volume":"87","author":"Erro R.","year":"2016","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25102"},{"key":"e_1_2_10_14_1","unstructured":"N.AliandM. A.Moutlak \u201cDemystifying SWEDD Syndrome: Scans Without Evidence of Dopaminergic Deficit. Geriatric Medicine \u201dhttps:\/\/pavilionhealthtoday.com\/gm\/demystifying\u2010swedd\u2010syndrome\u2010scans\u2010without\u2010evidence\u2010of\u2010dopaminergic\u2010deficit\/ accessed Nov 14 2024."},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.arr.2015.12.009","article-title":"Molecular Imaging of Dopamine Transporters","volume":"30","author":"Brooks D. 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