{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:54:23Z","timestamp":1781690063884,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["ANRS 0255"],"award-info":[{"award-number":["ANRS 0255"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["ANRS 0691b"],"award-info":[{"award-number":["ANRS 0691b"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CPT Pharmacom &amp; Syst Pharma"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cabotegravir (CAB), combined with rilpivirine, is the first long\u2010acting injectable therapy approved for HIV\u20101 maintenance treatment. While adherence and patient satisfaction have been improved, pharmacokinetic (PK) variability remains a concern. Two population PK models have been developed: one based on data from phase I\u2013III trials and the other on routine clinical data. However, neither model has undergone thorough external evaluation. The aim of this study was to evaluate the predictive performance of these models using an independent prospective dataset to evaluate their suitability to support model\u2010informed precision dosing (MIPD). External validation was performed using data from the French observational and multicenter (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914) ANRS0255 CARLAPOP study (736 HIV\u2010infected patients, representing 2192 concentrations). Models were implemented using MONOLIX software and evaluated using goodness\u2010of\u2010fit, prediction\u2010based, and simulation\u2010based diagnostics. For Han's model, regarding plasma concentrations following intramuscular administration, Median Prediction Error (MDPE) was \u22121.2% (PRED) and \u22124.4% (IPRED); Median Absolute Prediction Error (MDAPE) was 36.6% (PRED) and 17.9% (IPRED). For Thoueille's model, MDPE was \u221224.2% (PRED) and \u22129.2% (IPRED); MDAPE was 39.0% (PRED) and 15.3% (IPRED). However, &lt;\u200970% of predictions were within a 20% error margin with both models. Graphical analyses of Thoueille's model showed systemic bias, particularly in women, nonsmokers, and patients with higher body mass index. Therefore, neither model was considered reliable enough for MIPD application in our population. Although Han et\u00a0al.'s model demonstrated higher predictive performances, further improvements are required before it can be reliably applied for MIPD in daily routine.\n                  <\/jats:p>","DOI":"10.1002\/psp4.70180","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T09:51:21Z","timestamp":1779443481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["External Evaluation of Population Pharmacokinetic Models of Cabotegravir, During Its Oral and Intramuscular Administration in\n                    <scp>HIV<\/scp>\n                    \u2010Infected Patients"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6019-1288","authenticated-orcid":false,"given":"Quentin","family":"Renou","sequence":"first","affiliation":[{"name":"Unit\u00e9 des Virus \u00c9mergents (UVE: Aix\u2010Marseille Univ\u2010IRD 190\u2010Inserm 1207)  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9193-1120","authenticated-orcid":false,"given":"Nad\u00e8ge","family":"N\u00e9ant","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital La Timone, Laboratoire de Pharmacocin\u00e9tique et Toxicologie, Unit\u00e9 des Virus \u00c9mergents (UVE: Aix\u2010Marseille Univ\u2010IRD 190\u2010Inserm 1207)  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-9201","authenticated-orcid":false,"given":"Alexandre","family":"Destere","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Universit\u00e9 C\u00f4te d'Azur Medical Centre  Nice France"},{"name":"Universit\u00e9 C\u00f4te d'Azur, Inria, CNRS, Laboratoire J.A. Dieudonn\u00e9, Maasai Team  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2405-4778","authenticated-orcid":false,"given":"Jennifer","family":"Lagoutte\u2010Renosi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Marie et Louis Pasteur, CHU Besan\u00e7on, SINERGIES (UR 4662)  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1232-5761","authenticated-orcid":false,"given":"Matthieu","family":"Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Service de Pharmacologie Clinique  Nantes France"},{"name":"Nantes Universit\u00e9, CHU Nantes, Cibles et m\u00e9dicaments des Infections et de l'immunit\u00e9, 9 IICiMed, UR 1155  Nantes 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CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail)\u2010UMR_S 1085  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4385-7894","authenticated-orcid":false,"given":"Peggy","family":"Gandia","sequence":"additional","affiliation":[{"name":"INTHERES, Universit\u00e9 de Toulouse, INRAE, ENVT  Toulouse France"},{"name":"Laboratoire de Pharmacocin\u00e9tique et Toxicologie, CHU de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7466-6388","authenticated-orcid":false,"given":"Nicolas","family":"Venisse","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, CNRS \u2013 UMR 7267, CHU de Poitiers, Service de Toxicologie et Pharmacocin\u00e9tique et INSERM\u2010CIC 1402  Poitiers 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