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This study developed a physiologically based pharmacokinetic (PBPK) model using European data from patients with hepatic\/renal impairment and drug\u2013drug interaction (DDI) studies (itraconazole, rifampin). The model was then applied to predict (1) pharmacokinetics (PK) in the Chinese population; (2) PK in Chinese patients with hepatic\/renal impairment; and (3) DDI in Chinese patients. Validated against clinical data, the model successfully predicted brigatinib PK alone and with CYP3A4 modulators. Food simulations showed a slight absorption delay without clinically meaningful exposure reduction. In hepatic\/renal impairment, the model accurately predicted exposure changes across severity groups (fold error &lt;\u20092). Extending the European\u2010validated model to Chinese populations, the findings demonstrate reliable predictions of brigatinib PK in Chinese individuals as well as in Chinese patients with hepatic or renal impairment.<\/jats:p>","DOI":"10.1002\/psp4.70302","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:23:16Z","timestamp":1784690596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physiologically Based Pharmacokinetic Model of Brigatinib in Healthy Volunteers and Patients With Cancer"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0476-9787","authenticated-orcid":false,"given":"Yichao","family":"Xu","sequence":"first","affiliation":[{"name":"Center of Clinical Pharmacology Second Affiliated Hospital of Zhejiang University  Hangzhou 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