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Based on simulations, we show that the current practice of ignoring centre heterogeneity can be seriously misleading, and we illustrate the performances of the frailty modelling approach over competing methods. A special attention is paid to the problem of misspecification of the frailty distribution. The appendix provides sample codes in <jats:styled-content>R<\/jats:styled-content> and in <jats:styled-content>SAS<\/jats:styled-content> to perform the analyses in this paper. 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