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While the majority of dose finding designs for such setting were proposed for oncology trials, the corresponding designs are also essential in other therapeutic areas. Furthermore, there is increased recognition of recommending the patient\u2010specific doses\/combinations, rather than a single target one that would be recommended to all patients in later phases regardless of their characteristics. In this paper, we propose a dose\u2010finding design for a dual\u2010agent combination trial motivated by an opiate detoxification trial. The distinguishing feature of the trial is that the (continuous) dose of one compound is defined externally by the clinicians and is individual for every patient. The objective of the trial is to define the dosing function that for each patient would recommend the optimal dosage of the second compound. Via a simulation study, we have found that the proposed design results in high accuracy of individual dose recommendation and is robust to the model misspecification and assumptions on the distribution of externally defined doses.<\/jats:p>","DOI":"10.1002\/pst.2181","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:59:09Z","timestamp":1639184349000},"page":"476-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A dose\u2010finding design for dual\u2010agent trials with patient\u2010specific doses for one agent with application to an opiate detoxification trial"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6810-0284","authenticated-orcid":false,"given":"Pavel","family":"Mozgunov","sequence":"first","affiliation":[{"name":"MRC Biostatistics Unit University of Cambridge  Cambridge 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