{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:15:48Z","timestamp":1790252148348,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T00:00:00Z","timestamp":1237507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutical Statistics"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The assessment of overall homogeneity of time\u2010to\u2010event curves is a key element in survival analysis in biomedical research. The currently commonly used testing methods, e.g. log\u2010rank test, Wilcoxon test, and Kolmogorov\u2013Smirnov test, may have a significant loss of statistical testing power under certain circumstances. In this paper we propose a new testing method that is robust for the comparison of the overall homogeneity of survival curves based on the absolute difference of the area under the survival curves using normal approximation by Greenwood's formula. Monte Carlo simulations are conducted to investigate the performance of the new testing method compared against the log\u2010rank, Wilcoxon, and Kolmogorov\u2013Smirnov tests under a variety of circumstances. The proposed new method has robust performance with greater power to detect the overall differences than the log\u2010rank, Wilcoxon, and Kolmogorov\u2013Smirnov tests in many scenarios in the simulations. Furthermore, the applicability of the new testing approach is illustrated in a real data example from a kidney dialysis trial. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pst.376","type":"journal-article","created":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T17:02:15Z","timestamp":1237568535000},"page":"67-76","source":"Crossref","is-referenced-by-count":23,"title":["A new method for the comparison of survival distributions"],"prefix":"10.1002","volume":"9","author":[{"given":"Xun","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"205","article-title":"Asymptotically efficient rank invariant test procedures","volume":"34","author":"Peto R","year":"1972","journal-title":"The Journal of Royal Statistical Society"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529620"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/64.1.156"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/62.2.425"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/2530120"},{"key":"e_1_2_1_7_2","first-page":"124","article-title":"Censoring and stochastic integrals","author":"Gill RD","year":"1980","journal-title":"Mathematical Centre Tracts"},{"key":"e_1_2_1_8_2","volume-title":"Survival analysis, techniques for censored and truncated data","author":"Klein J","year":"1998"},{"key":"e_1_2_1_9_2","volume-title":"Applied survival analysis","author":"Hosmer DW","year":"1999"}],"container-title":["Pharmaceutical Statistics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpst.376","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pst.376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T18:25:50Z","timestamp":1700591150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pst.376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,20]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1002\/pst.376"],"URL":"https:\/\/doi.org\/10.1002\/pst.376","archive":["Portico"],"relation":{},"ISSN":["1539-1604","1539-1612"],"issn-type":[{"value":"1539-1604","type":"print"},{"value":"1539-1612","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,20]]}}}