{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:53:31Z","timestamp":1768877611063,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2002,10,30]],"date-time":"2002-10-30T00:00:00Z","timestamp":1035936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to carry out a controlled pilot study on the putative anxiolytic effect of valepotriates. Thirty\u2010six outpatients with generalized anxiety disorder (DSM III\u2010R), after a 2\u2010week wash\u2010out, were randomized to one of the following three treatments for 4 weeks (<jats:italic>n<\/jats:italic>\u2005=\u200512 per group): valepotriates (mean daily dose: 81.3\u2005mg), diazepam (mean daily dose: 6.5\u2005mg), or placebo. A parallel, double\u2010blind, flexible\u2010dose, placebo\u2010controlled design was employed. No significant difference was observed among the three groups at baseline or in the change from baseline on the Hamilton anxiety scale (HAM\u2010A) or in the trait part of the state\u2010trait anxiety inventory (STAI\u2010trait). Moreover, the three groups presented a significant reduction in the total HAM\u2010A scores. On the other hand, only the diazepam and valepotriates groups showed a significant reduction in the psychic factor of HAM\u2010A. The diazepam group also presented a significant reduction of the STAI\u2010trait. Although the principal analysis (HAM\u2010A between group comparison) found negative results (probably due to the small sample size in each group), the preliminary data obtained in the present study suggest that the valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety. However, since the number of subjects per group was very small, the present results must be viewed as preliminary. Thus, further studies addressing this issue are warranted. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1027","type":"journal-article","created":{"date-parts":[[2002,10,31]],"date-time":"2002-10-31T18:19:37Z","timestamp":1036088377000},"page":"650-654","source":"Crossref","is-referenced-by-count":115,"title":["Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo\u2010controlled pilot study"],"prefix":"10.1002","volume":"16","author":[{"given":"Roberto","family":"Andreatini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e2nia A.","family":"Sartori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L. V.","family":"Seabra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Roberto","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,10,30]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders \u2014 DSM III\u2010R","year":"1987"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90342-5"},{"key":"e_1_2_1_4_1","first-page":"259","article-title":"Idate tra\u00e7o: adapta\u00e7\u00e3o para avalia\u00e7\u00e3o da ansiedade durante sete dias. [STAI\u2010trait: adaptation for anxiety evaluation during seven days]","volume":"43","author":"Andreatini R","year":"1994","journal-title":"J Bras Psiq"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432503"},{"issue":"326","key":"e_1_2_1_6_1","first-page":"1","article-title":"Mini\u2010compendium of rating scales for states of anxiety, depression, mania and schizophrenia with corresponding DSM III syndromes","volume":"73","author":"Bech P","year":"1986","journal-title":"Acta Psychiatr Scand"},{"key":"e_1_2_1_7_1","first-page":"29","volume-title":"Cross\u2010cultural Research on Anxiety","author":"Biaggio AM","year":"1976"},{"key":"e_1_2_1_8_1","first-page":"284","volume-title":"Progress in Basic and Clinical Pharmacology","author":"Bolan R","year":"1990"},{"key":"e_1_2_1_9_1","first-page":"151","article-title":"Efeito de uma mistura de valepotriatos na resposta de ansiedade induzida em volunt\u00e1rios submetidos a uma situa\u00e7\u00e3o de estresse psicol\u00f3gico. [Effect of valepotriates in the response of induced anxiety in volunteers submitted to a psychological stressing situation.]","volume":"106","author":"B\u00fccker EOG","year":"1993","journal-title":"F M\u00e9dica (BR)"},{"key":"e_1_2_1_10_1","unstructured":"B\u00fcckerEOG RibeiroRA AndreatiniR LeiteJR.1993b.Estudo sobre a a\u00e7\u00e3o de valepotriatos (Valmane) no labirinto em cruz elevado.[A study of the valepotriate action Valmane) in the elevated plus\u2010maze]Summaries of VII Annual Meeting of the Federation of Societies of Experimental Biology \u2014FESBE S\u00e3o Paulo Brazil."},{"issue":"1","key":"e_1_2_1_11_1","first-page":"3","article-title":"Generalized anxiety disorder: new concepts and psychopharmacologic treatments","volume":"51","author":"Dubovsky SL","year":"1990","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_12_1","first-page":"2087","article-title":"Understanding the use of behavioral rating scales in studies evaluating the efficacy of antianxiety and antidepressant drugs","volume":"44","author":"Fankenhaeuser MP","year":"1987","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_1_13_1","first-page":"1535","volume-title":"Psychopharmacology: The Third Generation of Progress","author":"Griffiths RR","year":"1987"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991772772"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1986.01800010081010"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1017047"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-969430"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90082-8"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00404739"},{"key":"e_1_2_1_21_1","first-page":"373","volume-title":"Clinical Evaluations of Psychotropic Drugs: Principles and Guidelines","author":"Rickels K","year":"1994"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0944-7113(97)80050-5"},{"key":"e_1_2_1_23_1","volume-title":"Manual for the State\u2010Trait Anxiety Inventory","author":"Spielberg CD","year":"1970"},{"key":"e_1_2_1_24_1","volume-title":"Structured Clinical Interview for DSM\u2010III\u2010R \u2014 Patient Edition (SCID\u2010P, version 1.0).","author":"Spitzer RL","year":"1990"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1027","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T08:21:23Z","timestamp":1700295683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,30]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1002\/ptr.1027"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1027","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10,30]]}}}