{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T21:18:28Z","timestamp":1722892708018},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2002,11,28]],"date-time":"2002-11-28T00:00:00Z","timestamp":1038441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"La Universided de La Laguna"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The infusions of the aerial parts in blossom of <jats:italic>Hypericum canariense<\/jats:italic>, <jats:italic>H. glandulosum<\/jats:italic>, <jats:italic>H. reflexum<\/jats:italic> and <jats:italic>H. grandifolium<\/jats:italic> (Hypericaceae) were evaluated for their pharmacological activity on the central nervous system in mice using various behavioural models including locomotor and muscle relaxant activity, effect on normal body temperature, pentobarbital\u2010induced sleep, oxotremorine and tetrabenazine\u2010induced syndrome, apomorphine\u2010induced hypothermia and 5\u2010hydroxytryptophan\u2010induced head twitches, as well as a forced swimming test. These infusions did not alter significantly the locomotor activity, pentobarbital induced sleeping time and body temperature, with the exception of <jats:italic>H. canariense<\/jats:italic> which produced a slight but significant hypothermia. Additionally, no muscle relaxant or anticholinergic activity were observed. These infusions antagonized the ptosis and\/or motor depression induced by tetrabenazine as well as shortening the immobility time in the forced swimming test. The observations suggest that the infusions of these <jats:italic>Hypericum<\/jats:italic> species possess antidepressant activity in mice, without inducing muscle relaxation, anticholinergic and sedative properties. 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