{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:42:46Z","timestamp":1764171766563},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,2,10]],"date-time":"2003-02-10T00:00:00Z","timestamp":1044835200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enteric\u2010coated preparations containing a fixed peppermint oil\/caraway oil combination (e.g. Enteroplant\u00ae) are widely used in patients with functional dyspepsia. The effect of a separate intraduodenal application of the active ingredients of Enteroplant\u00ae (90\u2005mg peppermint oil (WS\u00ae 1340), 50\u2005mg caraway oil (WS\u00ae 1520) per capsule) and of a hydrophobic phase galenic auxiliary material contained in the Enteroplant\u00ae formulation (dose as contained per capsule) on gastroduodenal motility were studied with stationary manometry in healthy volunteers. The carrier demanded by the experimental setup also served as a control. The results showed that: (1) during phase III of the migrating motor complex (MMC) the frequency and duration of contractions showed a significant decrease in the duodenum for WS\u00ae 1340; (2) WS\u00ae 1520 significantly reduced the contraction amplitudes in the duodenum during phase I and II of the MMC; (3) trends for decreased values were seen for WS\u00ae 1340 in the gastric corpus and duodenum and for WS\u00ae 1520 in the gastric antrum; (4) in the gastric corpus the duration of contractions was significantly reduced after application of WS\u00ae 1340 during phases I and II of the MMC; (5) WS\u00ae 1520 significantly reduced the contraction amplitudes and the duration of contractions in the gastric corpus during phase III of the MMC; (6) for the hydrophobic phase a moderate but significant decrease of duration of contractions in the duodenum and of frequency of contractions in the gastric corpus was seen. No adverse events were observed during the study. In conclusion, it could be shown that both WS\u00ae 1340 and WS\u00ae 1520 contribute to the efficacy of Enteroplant\u00ae. They act locally in the stomach and duodenum to produce smooth\u2010muscle relaxation. The effects of the active ingredients WS\u00ae 1340 and WS\u00ae 1520 substantially exceed the effects observed with the galenic auxiliary material and the carrier, respectively. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1089","type":"journal-article","created":{"date-parts":[[2003,2,25]],"date-time":"2003-02-25T13:59:31Z","timestamp":1046181571000},"page":"135-140","source":"Crossref","is-referenced-by-count":40,"title":["Effects of intraduodenal application of peppermint oil (WS\u00ae 1340) and caraway oil (WS\u00ae 1520) on gastroduodenal motility in healthy volunteers"],"prefix":"10.1002","volume":"17","author":[{"given":"George","family":"Micklefield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmgard","family":"Greving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkard","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,2,10]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1984.tb01206.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1742-1241.1984.tb07744.x","article-title":"Peppermint oil for the irritable bowel syndrome: A multicentre trial","volume":"38","author":"Dew MJ","year":"1984","journal-title":"Br J Clin Pract"},{"key":"e_1_2_1_4_1","first-page":"820","article-title":"The effect of peppermint oil on colonic motility in man","volume":"68","author":"Duthie HL","year":"1981","journal-title":"Br J Sur"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90459-X"},{"key":"e_1_2_1_6_1","first-page":"925","article-title":"Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride","volume":"49","author":"Madisch A","year":"1999","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00873.x"},{"key":"e_1_2_1_8_1","first-page":"1149","article-title":"Efficacy of a fixed peppermint oil\/caraway oil combination in non\u2010ulcer dyspepsia","volume":"46","author":"May B","year":"1996","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1742-1241.1986.tb07981.x","article-title":"Peppermint oil does not relieve the pain of irritable bowel syndrome","volume":"40","author":"Nash P","year":"1986","journal-title":"Br J Clin Pract"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018950930134"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6194.835"},{"key":"e_1_2_1_12_1","first-page":"408","article-title":"Relaxant effects on tracheal and ileal smooth muscles of the guinea pig","volume":"35","author":"Reiter M","year":"1985","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.2.129"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1984.tb02519.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-68-812-841"},{"key":"e_1_2_1_16_1","first-page":"A992","article-title":"Inhibitory effect of peppermint oil on gastrointestinal smooth muscle","volume":"24","author":"Taylor BA","year":"1983","journal-title":"Gut"},{"key":"e_1_2_1_17_1","first-page":"A1168","article-title":"Inhibitory effect of peppermint and menthol on human isolated coli","volume":"25","author":"Taylor BA","year":"1984","journal-title":"Gut"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.25.3.305"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018823512901"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:31:58Z","timestamp":1700245918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["10.1002\/ptr.1089"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1089","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}