{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:33:29Z","timestamp":1791603209662,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,3,27]],"date-time":"2003-03-27T00:00:00Z","timestamp":1048723200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The leaves of <jats:italic>Perilla frutescens<\/jats:italic> Britton (Labiatae) are one of the most popular garnishes in Japan, used as an antidote for \ufb01sh and crab meat allergy or as a food colorant. The present study was conducted to evaluate its anti\u2010allergic effect and to identify its active constituents using mice ear\u2010passive cutaneous anaphylaxis (PCA)\u2010reaction. 48\u00a0h after the cutaneous injection of anti\u2010ovalbumin serum into the ears of mice, ovalbumin and evansblue dye were intravenously injected. Perilla was extracted with boiling water, and intraperitoneally injected 15 min before ovalbumin\u2010treatment. Thirty min after ovalbumin\u2010treatment, the ears were removed and the colorant in the ear was colorimetrically quantitated. Perilla extract signi\ufb01cantly suppressed the PCA\u2010reaction, which was brought about by rosmarinic acid with a partial contribution from some macromolecular compounds. The anti\u2010allergic titer of rosmarinic acid was more effective than tranilast, which is a modern anti\u2010allergic drug. Perilla and rosmarinic acid are potentially promising agents for the treatment of allergic diseases. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1115","type":"journal-article","created":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T04:16:47Z","timestamp":1106194607000},"page":"240-243","source":"Crossref","is-referenced-by-count":116,"title":["Anti\u2010allergic effect of <i>Perilla frutescens <\/i>and its active constituents"],"prefix":"10.1002","volume":"17","author":[{"given":"Toshiaki","family":"Makino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannosuke","family":"Wakushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9802777"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.34.1672"},{"key":"e_1_2_1_4_1","first-page":"74","article-title":"Effect of Perilla frutescens extract on anti\u2010DNP IgE antibody production in mice","volume":"42","author":"Imaoka K","year":"1993","journal-title":"Jpn J Allergol"},{"key":"e_1_2_1_5_1","first-page":"257","article-title":"Chinese herbal medicines capable of IgE antibody suppression and interferon induction","volume":"12","author":"Imaoka K","year":"1995","journal-title":"J Tradional Med"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000233523"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000234681"},{"key":"e_1_2_1_8_1","first-page":"443","article-title":"Inhibition of antigen\u2010speci\ufb01c T helper type 2 responses by Perilla frutescens extract","volume":"48","author":"Ishihara","year":"1999","journal-title":"Allergy"},{"key":"e_1_2_1_9_1","first-page":"369","article-title":"IPD\u20101151T: a prototype drug for IgE antibody synthesis modulation","volume":"34","author":"Koda A","year":"1991","journal-title":"Agents Actions Suppl"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-969568"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.46.159"},{"key":"e_1_2_1_12_1","first-page":"71","volume-title":"Perilla, the Genus Perilla","author":"Oyanagi K","year":"1997"},{"key":"e_1_2_1_13_1","first-page":"242","article-title":"Screening for mast cell histamine release inhibitory activity of Philippine medicinal plants. Active constituent of Ehretia microphylla","volume":"41","author":"Rimando AM","year":"1987","journal-title":"Shoyakugaku Zasshi"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923970009026007"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:20:33Z","timestamp":1700259633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1002\/ptr.1115"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1115","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}