{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:25:27Z","timestamp":1759962327267},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T00:00:00Z","timestamp":1050364800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Amburana cearensis<\/jats:italic> A. C. Smith, Fagaceae, is a medicinal plant commonly known as \u2018cumaru\u2019 and used in Northeast Brazil for the treatment of respiratory tract diseases. In the present work, we investigated the anti\u2010in\ufb02ammatory and smooth muscle relaxant activities of the hydroalcoholic extract (HAE), coumarin (Coum) and \ufb02avonoid fraction (FF) isolated from the trunk barks of <jats:italic>Amburana cearensis<\/jats:italic> A. C. Smith. It was shown that HAE (200 and 400\u00a0mg\/kg), Coum (20 and 40\u00a0mg\/kg) and FF (40\u00a0mg\/kg), administered orally, signi\ufb01cantly inhibited both leukocyte and neutrophil migrations, in the carrageenan or N\u2010formyl\u2010methyl\u2010leucyl\u2010phenylalanine (fMLP)\u2010induced migration in rat peritoneal cavity. The increase in cutaneous vascular permeability induced by serotonin in rats was signi\ufb01cantly blocked by HAE (150\u00a0mg\/kg, i.p.), Coum (5\u00a0mg\/kg, i.p.) and FF (20\u00a0mg\/kg, i.p.). However, only HAE blocked the histamine effect on Evans blue extravasation. In the guinea\u2010pig trachea precontracted with carbachol (0.3\u00a0\u00b5M), histamine (0.1\u00a0\u00b5M) or KCl (0.1\u00a0M), the HAE, Coum and FF evoked a concentration\u2010dependent relaxation in the presence of the three agonists. HAE (100\u2013800\u00a0\u00b5g\/ml) and Coum (4\u201332\u00a0\u00b5g\/ml) also caused signi\ufb01cant relaxation of the rat vas deferens previously contracted with adrenaline, acetylcholine or barium chloride. In addition, HAE, Coum and FF inhibited the histamine and serotonin\u2010induced increase of cutaneous vascular permeability in rats. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1139","type":"journal-article","created":{"date-parts":[[2003,4,25]],"date-time":"2003-04-25T13:26:04Z","timestamp":1051277164000},"page":"335-340","source":"Crossref","is-referenced-by-count":34,"title":["Anti\u2010in\ufb02ammatory and smooth muscle relaxant activities of the hydroalcoholic extract and chemical constituents from <i>Amburana cearensis<\/i> A. C. Smith"],"prefix":"10.1002","volume":"17","author":[{"given":"L. K. A. M.","family":"Leal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nechio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. R.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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