{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T14:49:13Z","timestamp":1760798953664},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T00:00:00Z","timestamp":1032220800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Arbutus unedo<\/jats:italic> L. (Ericaceae) is used in oriental Morocco to treat arterial hypertension. We studied its vasodilator effect and mechanisms of action <jats:italic>in vitro<\/jats:italic>. The root aqueous extract of Arbutus (0.25\u2005mg\/mL) produced a relaxation of noradrenaline\u2010precontracted ring preparations of rat aorta with intact endothelium. Relaxation by Arbutus did not occur in specimens without endothelium and was inhibited by pretreatment with 100\u2005\u03bc<jats:sc>M<\/jats:sc> N<jats:sup>G<\/jats:sup>\u2010methyl\u2010<jats:sc>L<\/jats:sc>\u2010arginine (<jats:sc>L<\/jats:sc>\u2010NMA), 10\u2005\u03bc<jats:sc>M<\/jats:sc> methylene blue or 50\u2005\u03bc<jats:sc>M<\/jats:sc> 1H\u2010[1,2,4] oxadiazolo [4,3\u2010a] quinoxaline\u20101\u2010one (ODQ) but not by 10\u2005\u03bc<jats:sc>M<\/jats:sc> atropine. These results suggest that Arbutus produces an endothelium\u2010dependent relaxation of the isolated rat aorta which may be mediated mainly by a stimulation of the endothelial nitric oxide synthase by mechanisms other than activation of muscarinic receptors. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1143","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T02:15:40Z","timestamp":1034129740000},"page":"572-575","source":"Crossref","is-referenced-by-count":34,"title":["<i>Arbutus unedo<\/i> induces endothelium\u2010dependent relaxation of the isolated rat aorta"],"prefix":"10.1002","volume":"16","author":[{"given":"Abderrahim","family":"Ziyyat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassane","family":"Mekhfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Bnouham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelhafid","family":"Tahri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelkhaleq","family":"Legssyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Hoerter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolphe","family":"Fischmeister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.52.3.482"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.12.2324"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199902000-00011"},{"key":"e_1_2_1_5_1","first-page":"185","article-title":"Les flavono\u00efdes de Arbutus unedo L. 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