{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:15:33Z","timestamp":1786950933625,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the antioxidant activity of mustard leaf (<jats:italic>Brassica juncea<\/jats:italic>), we prepared four fractions (CH<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub>, EtOAc, BuOH and H<jats:sub>2<\/jats:sub>O fractions) and examined their radical scavenging activities <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Based on the <jats:italic>in vitro<\/jats:italic> results of spin trapping and 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl radical, we carried out an <jats:italic>in vivo<\/jats:italic> study with the BuOH fraction to investigate its effect on oxidative stress in rats with streptozotocin\u2010induced diabetes. We found that in comparison with untreated diabetic control rats, oral administration of the BuOH fraction (100 or 200\u00a0mg\/kg body weight\/day for 10 days) induced a signi\ufb01cant decrease in serum glucose and glycosylated protein, which is glycosylated with hemoglobin as an indicator of oxidative stress. Moreover, administration of the BuOH fraction also effectively reduced the serum superoxide and nitrite\/nitrate levels. Furthermore, the levels of thiobarbituric acid\u2010reactive substances in serum and liver were also signi\ufb01cantly lower than in the control group. These results indicate that the BuOH fraction of mustard leaf controls glucose metabolism and reduces lipid peroxidation as well as the level of oxygen radicals, ameliorating the damage caused by oxidative stress in diabetes. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1174","type":"journal-article","created":{"date-parts":[[2003,5,12]],"date-time":"2003-05-12T11:31:39Z","timestamp":1052739099000},"page":"465-471","source":"Crossref","is-referenced-by-count":39,"title":["<i>In Vitro <\/i>and<i> in vivo<\/i> antioxidant effects of mustard leaf (<i>Brassica juncea<\/i>)"],"prefix":"10.1002","volume":"17","author":[{"given":"Hyun","family":"Young Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Yokozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun","family":"Ju Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Sik Cheigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae","family":"Sue Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae","family":"Young Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.1995.tb05668.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/food.19960400506"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.4.405"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.50.070181.002125"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.635569"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9602535"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(95)00168-9"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-566506-3.50019-4"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-7460-1_4"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1995.0014"},{"key":"e_1_2_1_12_1","first-page":"150","volume-title":"Spices, Condiments, and Seasonings","author":"Farrell KT","year":"1985"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(76)80969-6"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.12.4533"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"e_1_2_1_16_1","first-page":"2","volume-title":"Antioxidant Methodology In Vivo and In Vitro Concepts","author":"Hall CA","year":"1997"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.1.5.2824268"},{"key":"e_1_2_1_18_1","first-page":"246","volume-title":"Free Radicals in Biology and Medicine","author":"Halliwell B","year":"1999"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/12.3.257"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.37.2016"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.21273\/JASHS.112.2.309","article-title":"Variation in glucosinolates in oriental Brassica vegetables","volume":"112","author":"Hill CB","year":"1987","journal-title":"J Am Soc Hort Sci"},{"key":"e_1_2_1_22_1","first-page":"183","article-title":"Association of lipid peroxidation and polymerization of membrane proteins with erythrocyte aging","volume":"40","author":"Hochstein P","year":"1981","journal-title":"Fed Proc"},{"key":"e_1_2_1_23_1","volume-title":"Antioxidants and Cancer Prevention; ACS Symposium Series 507","author":"Huang MT","year":"1992"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-0753-9"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(64)90200-3"},{"key":"e_1_2_1_26_1","first-page":"13","article-title":"Effects of mustard leaf (Brassica juncea) on cholesterol metabolism in rats","volume":"26","author":"Jo YS","year":"1993","journal-title":"Kor J Nutr"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01322333"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(88)80254-1"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(95)01246-A"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.1.6.3315807"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.28.11.1011"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(88)90001-2"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09915.x"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1993.1449"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-998-0258-y"},{"key":"e_1_2_1_36_1","first-page":"187","article-title":"Atherosclerotic disorder and lipid peroxidation","volume":"15","author":"Naito C","year":"1978","journal-title":"Jpn J Geriatr"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9508357"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9561-8_11"},{"key":"e_1_2_1_39_1","first-page":"91","article-title":"Studies on the diabetogenic action of streptozotocin","volume":"29","author":"Rakieten N","year":"1963","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_1_40_1","first-page":"45","volume-title":"Free Radicals and Biological Defense","author":"Shimazaki H","year":"1994"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2220001"},{"key":"e_1_2_1_42_1","first-page":"563","article-title":"Changes in chlorophylls and carotenoids of mustard leaf kimchi during fermentation and their antioxidative activities on the lipid oxidation","volume":"26","author":"Song ES","year":"1997","journal-title":"J Kor Soc Food Sci Nutr"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1355616"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1281928"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90040-X"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9801973"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(87)90014-5"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf950579y"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00122a059"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2450243"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02660723"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf000253b"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1174","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T11:29:30Z","timestamp":1700220570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["10.1002\/ptr.1174"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1174","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}