{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:10:39Z","timestamp":1761016239559},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several extracts from marine brown alga <jats:italic>Sargassum micracanthum<\/jats:italic> (Kuetzing) Endlicher were screened for their inhibitory activity on lipid peroxidation. In an <jats:italic>in vitro<\/jats:italic> study, methanol extract (Sm\u2010M), chloroform\/ methanol (3:1) extract and ethyl acetate fraction of Sm\u2010M inhibited lipid peroxidation in rat liver homo\u2010genates. The IC<jats:sub>50<\/jats:sub> values were 0.70, 0.70 and 0.37\u00a0\u00b5g\/mL, respectively. These inhibitions were stronger than vitamine C and E. These extracts showed reductive activity on DPPH, the IC<jats:sub>50<\/jats:sub> values were 34, 37 and 11\u00a0\u00b5g\/mL, respectively. In an <jats:italic>in vivo<\/jats:italic> study, Sm\u2010M had the effect on CCl4 induced liver injury in rats and Sm\u2010M (120\u20131200\u00a0mg\/kg, p.o.) lowered dose\u2010dependently the level of lipid peroxidation in liver. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1194","type":"journal-article","created":{"date-parts":[[2003,5,12]],"date-time":"2003-05-12T11:31:39Z","timestamp":1052739099000},"page":"549-551","source":"Crossref","is-referenced-by-count":19,"title":["Inhibitory activity on lipid peroxidation of extracts from marine brown alga"],"prefix":"10.1002","volume":"17","author":[{"given":"Jun","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90572-E"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/1811199a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7403881"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1986.tb12952.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1979.1181"},{"key":"e_1_2_1_7_1","first-page":"19","article-title":"Hondawara Ka Kassyokusoucyu no Terupen Rui","author":"Kusumi T","year":"1979","journal-title":"Terupen oyobi Seiyukagaku ni kansuru Toronkai"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)88273-8"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)81208-9"},{"key":"e_1_2_1_10_1","first-page":"7134","article-title":"The role of reduced nicotinamide adenine dinucleotide phosphate\u2010cytochrome c reductase in liver microsomal lipid peroxidation","volume":"248","author":"Pederson TC","year":"1973","journal-title":"J Biol Chem"},{"key":"e_1_2_1_11_1","first-page":"145","article-title":"Carbon tetrachloride hepatotoxicity","volume":"19","author":"Richard OR","year":"1967","journal-title":"Pharmac Rev"},{"key":"e_1_2_1_12_1","unstructured":"1985 CMC Co. 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