{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T22:29:46Z","timestamp":1774823386203,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2003,12,5]],"date-time":"2003-12-05T00:00:00Z","timestamp":1070582400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of guarana (<jats:italic>Paullinia cupana<\/jats:italic>) extract were analyzed in rats on acute gastric lesions induced by ethanol and indomethacin and were compared to those produced by caffeine, a methylxanthine. Guarana (50 and 100 mg\/kg p.o.) pretreated animals showed a signi\ufb01cant reduction in the severity of gastric lesions induced by absolute ethanol in a manner similar to caffeine (20 and 30 mg\/kg p.o.). Against indomethacin\u2010induced gastric ulceration, guarana at a higher dose offered signi\ufb01cant protection but caffeine was ineffective at the doses tested. In 4 h pylorus\u2010ligated rats, both guarana and caffeine caused signi\ufb01cant diminution in the gastric secretory volume as well as the total acidity. Gastrointestinal transit in mice was not signi\ufb01cantly affected by either of these agents. These \ufb01ndings indicate that guarana has a gastroprotective property that needs further elucidation as regards to its mechanism. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1212","type":"journal-article","created":{"date-parts":[[2003,12,8]],"date-time":"2003-12-08T08:01:53Z","timestamp":1070870513000},"page":"1199-1202","source":"Crossref","is-referenced-by-count":25,"title":["Guarana (<i>Paullinia cupana<\/i> Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats"],"prefix":"10.1002","volume":"17","author":[{"given":"A. R.","family":"Campos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. I. S.","family":"Barros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. A.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. S. 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