{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T12:26:08Z","timestamp":1749126368662},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,6,16]],"date-time":"2003-06-16T00:00:00Z","timestamp":1055721600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Pycnocycla spinosa<\/jats:italic> is an essential oil from a wild plant growing in central Iran. However, so far its pharmacological effects have not been studied. The aim of this study was to look for relaxant effects of the essential oil and hydro\u2010alcoholic extract of <jats:italic>P. spinosa<\/jats:italic> on rat isolated ileum contractions induced by KCl and acetylcholine (ACh). <jats:italic>P. spinosa<\/jats:italic> essential oil (PSEO) and the hydro\u2010alcoholic extract inhibited the response to 80 mM KCl in a concentration\u2010dependent manner and attenuated the maximum attainable response of ACh concentration\u2010response curve. Furthermore, in caster oil induced diarrhoea, the hydro\u2010alcoholic extract had a dose\u2010dependent anti\u2010diarrhoeal effect. This study showed that <jats:italic>P. spinosa<\/jats:italic> essential oil and its hydro\u2010alcoholic extract act as a relaxant of rat isolated ileum. As the inhibition of contractile over\u2010activity of the ileum is the basis for the treatment of gastro\u2010intestinal disorders such as diarrhoea, <jats:italic>P. spinosa<\/jats:italic> may have clinical bene\ufb01ts for treatment of this condition. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1217","type":"journal-article","created":{"date-parts":[[2003,6,18]],"date-time":"2003-06-18T10:14:59Z","timestamp":1055931299000},"page":"645-649","source":"Crossref","is-referenced-by-count":14,"title":["Relaxant effect of essential oil and hydro\u2010alcoholic extract of <i>Pycnocycla spinosa<\/i> Decne. exBoiss. on ileum contractions"],"prefix":"10.1002","volume":"17","author":[{"given":"H.","family":"Sadraei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Asghari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Naddafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,6,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-044230-0.50006-X"},{"key":"e_1_2_1_3_1","unstructured":"Pharmacopoeia British 1988 HMSO London A137 A138."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)81487-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1996.tb03980.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90414-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00209-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90459-X"},{"key":"e_1_2_1_9_1","first-page":"1037","volume-title":"Goodman & Gilman's the Pharmacological Basis of Therapeutics","author":"Jafri S","year":"2001"},{"key":"e_1_2_1_10_1","first-page":"443","volume-title":"A Dictionary of Iranian Plant Names","author":"Mozaffarian V","year":"1996"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.17-2025"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00052"},{"issue":"2","key":"e_1_2_1_13_1","first-page":"22","article-title":"Study of the inhibitory effect of two different source of Thymus vulgaris essential oil on ileum contraction in compare with available clinically used drug preparation of thymus","volume":"2","author":"Sadraei H","year":"2000","journal-title":"Sharekorerd Uni Med Sci J"},{"key":"e_1_2_1_14_1","first-page":"48","volume-title":"Drugs of Natural Origin","author":"Samuelsson G","year":"1999"},{"volume-title":"Monoterpenes: Infrared, Mass, 1H\u2010NMR and 13C\u2010NMR Spectra and Kovats indices","year":"1981","author":"Swigar AA","key":"e_1_2_1_15_1"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00647-0"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1217","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:30:23Z","timestamp":1700263823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1002\/ptr.1217"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1217","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"type":"print","value":"0951-418X"},{"type":"electronic","value":"1099-1573"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}